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Dendritic cells play a role in host susceptibility to Cryptosporidium parvum infection

Highlights • Depletion of DCs in vivo increases susceptibility to Cryptosporidium parvum infection. • Adoptive transfer of stimulated DCs reduces C. parvum infection levels. • Reduction in infection correlates to an increase in IFN-γ in T cell. • DCs pulsed with sporozoites and co-cultured with CD4+...

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Published in:	Immunology letters 2014-03, Vol.158 (1), p.42-51
Main Authors:	Bedi, Brahmchetna, McNair, Nina N, Mead, Jan R
Format:	Article
Language:	English
Subjects:	Adoptive Transfer Allergy and Immunology Animals CD11 Antigens - metabolism CD11c-DTR-Tg Cryptosporidiosis - immunology Cryptosporidium Cryptosporidium parvum - immunology Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Dendritic Cells - transplantation Diphtheria Toxoid - immunology Disease Susceptibility Humans Innate response Lymphocyte Activation - genetics Mice Mice, Inbred C57BL Mice, Transgenic Th1 Cells - immunology
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container_title	Immunology letters
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creator	Bedi, Brahmchetna McNair, Nina N Mead, Jan R
description	Highlights • Depletion of DCs in vivo increases susceptibility to Cryptosporidium parvum infection. • Adoptive transfer of stimulated DCs reduces C. parvum infection levels. • Reduction in infection correlates to an increase in IFN-γ in T cell. • DCs pulsed with sporozoites and co-cultured with CD4+ and CD8+ T cells produced higher IFN-γ levels.
doi_str_mv	10.1016/j.imlet.2013.11.015
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subjects	Adoptive Transfer Allergy and Immunology Animals CD11 Antigens - metabolism CD11c-DTR-Tg Cryptosporidiosis - immunology Cryptosporidium Cryptosporidium parvum - immunology Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Dendritic Cells - transplantation Diphtheria Toxoid - immunology Disease Susceptibility Humans Innate response Lymphocyte Activation - genetics Mice Mice, Inbred C57BL Mice, Transgenic Th1 Cells - immunology
title	Dendritic cells play a role in host susceptibility to Cryptosporidium parvum infection
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