TREM-1 modulation during early stages of dengue virus infection

Highlights • Evaluation of surface and soluble TREM-1 levels in DENV-infected patients was made. • A significant reduction of TREM-1 expression was observed in neutrophils. • Sera from DENV-infected patients exhibited significantly higher of soluble TREM-1 levels during the first 5 days after the sy...

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Bibliographic Details
Published in:Immunology letters 2014-03, Vol.158 (1), p.183-188
Main Authors: Ruiz-Pacheco, J.A, Vivanco-Cid, H, Izaguirre-Hernández, I.Y, Estrada-García, I, Arriaga-Pizano, L, Chacón-Salinas, R, Fonseca-Coronado, S, Vaughan, G, Ruiz Tovar, K, Rivera-Osorio, M.P, Escobar-Gutiérrez, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergy and Immunology
Cells, Cultured
Child
Dengue - immunology
Dengue virus
Dengue Virus - immunology
Disease Progression
Female
Gene Expression Regulation
Humans
Immunity, Innate
Immunomodulation
Innate immunity
Male
Membrane Glycoproteins - biosynthesis
Membrane Glycoproteins - blood
Membrane Glycoproteins - genetics
Middle Aged
Monocytes - immunology
Monocytes - virology
Neutrophils - immunology
Neutrophils - virology
Receptors, Immunologic - biosynthesis
Receptors, Immunologic - blood
Receptors, Immunologic - genetics
sTREM-1
TREM-1
Triggering Receptor Expressed on Myeloid Cells-1
Young Adult
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Summary:Highlights • Evaluation of surface and soluble TREM-1 levels in DENV-infected patients was made. • A significant reduction of TREM-1 expression was observed in neutrophils. • Sera from DENV-infected patients exhibited significantly higher of soluble TREM-1 levels during the first 5 days after the symptoms onset. • The increment of sTREM-1 could be a compensatory mechanism to counteract the inflammatory process elicited by DENV infection. • These data are the first to show the involvement of TREM-1 during DENV infection.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2014.01.003