Callithrix penicillata : A feasible experimental model for dengue virus infection

Highlights • The infected animals presented relevant signs of dengue disease. • The date showed a peaks of viremia and peaks of anti-DENV3 IgM. • The monocytosis, lymphocytosis, leucopenia and thrombocytopenia were observed. • We observed an increases of TNF-α and IFN-γ, late increase of IFN-γ. • Ca...

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Bibliographic Details
Published in:Immunology letters 2014-03, Vol.158 (1), p.126-133
Main Authors: Ferreira, Milene Silveira, de Castro, Paulo Henrique Gomes, Silva, Gilmara Abreu, Casseb, Samir Mansur Moraes, Dias Júnior, Antônio Gregório, Rodrigues, Sueli Guerreiros, Azevedo, Raimunda do Socorro da Silva, Silva, Matheus Fernandes Costa e, Zauli, Danielle Alves Gomes, Araújo, Márcio Sobreira Silva, Béla, Samantha Ribeiro, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Vasconcelos, Pedro Fernando da Costa
Format: Article
Language:English
Subjects:
Allergy and Immunology
Anemia - etiology
Animals
Antibodies, Viral - blood
Biomarkers - blood
Blood Coagulation
Callithrix - immunology
Cell Count
Creatinine - blood
Cytokines - blood
Dengue - complications
Dengue - immunology
Dengue Virus - immunology
Dengue virus infection
Disease Models, Animal
Experimental model
Feasibility Studies
Immune response
Immunoglobulin M - blood
Leukopenia - etiology
Non-human
Primate
Thrombocytopenia - etiology
Transaminases - blood
Viral Load
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Summary:Highlights • The infected animals presented relevant signs of dengue disease. • The date showed a peaks of viremia and peaks of anti-DENV3 IgM. • The monocytosis, lymphocytosis, leucopenia and thrombocytopenia were observed. • We observed an increases of TNF-α and IFN-γ, late increase of IFN-γ. • Callithrix penicillata is a feasible experimental model for dengue virus infection.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.12.008