DCIR interacts with ligands from both endogenous and pathogenic origin

Highlights • We compared the glycan specificity of the DC-expressed CLRs: DCIR and DC-SIGN. • DCIR and DC-SIGN have overlapping glycan specificities. • Novel DCIR ligands of endogenous and pathogen-related origin were discovered. • Unique DCIR and DC-SIGN ligands are defined. • The interaction of DC...

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Bibliographic Details
Published in:Immunology letters 2014-03, Vol.158 (1), p.33-41
Main Authors: Bloem, Karien, Vuist, Ilona M, van den Berk, Meike, Klaver, Elsenoor J, van Die, Irma, Knippels, Léon M.J, Garssen, Johan, García-Vallejo, Juan J, van Vliet, Sandra J, van Kooyk, Yvette
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Bacterial Proteins - agonists
C-type lectins
Candida albicans - immunology
Cell Adhesion Molecules - immunology
Cell Adhesion Molecules - metabolism
Cricetulus
Dendritic cell
Dendritic Cells - immunology
env Gene Products, Human Immunodeficiency Virus - agonists
Glycan
Glycosylation
HIV Envelope Protein gp120 - agonists
HIV-1 - immunology
Host-Pathogen Interactions - immunology
Humans
Keratinocytes - immunology
Lectins, C-Type - immunology
Lectins, C-Type - metabolism
Ligands
Membrane Glycoproteins - immunology
Membrane Glycoproteins - metabolism
Oligosaccharides - agonists
Pathogen and cancer
Polysaccharides - metabolism
Protein Binding - genetics
Receptors, Cell Surface - immunology
Receptors, Cell Surface - metabolism
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
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Summary:Highlights • We compared the glycan specificity of the DC-expressed CLRs: DCIR and DC-SIGN. • DCIR and DC-SIGN have overlapping glycan specificities. • Novel DCIR ligands of endogenous and pathogen-related origin were discovered. • Unique DCIR and DC-SIGN ligands are defined. • The interaction of DCIR with its ligands is influenced by the glycosylation of DCIR.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.11.007