Effect of dichloromethane fraction of Areca catechu nut on monoamines associated behaviors and tyramine pressor sensitivity in rodents

The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dich...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2014-03, Vol.27 (2), p.303-307
Main Authors: Khan, Shagufta, Abbas, Ghulam, Ahmed, Fahad Shabbir, Rahman, Attaur, Dar, Ahsana
Format: Article
Language:English
Subjects:
5-Hydroxytryptophan
Animals
Areca - chemistry
Behavior, Animal - drug effects
Biogenic Monoamines - metabolism
Blood Pressure - drug effects
Dopamine - metabolism
Female
Heart Rate - drug effects
Male
Methylene Chloride
Moclobemide - pharmacology
Monoamine Oxidase Inhibitors - pharmacology
Oxidases
Phenelzine - pharmacology
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
Serotonin - metabolism
Solvents
Stereotyped Behavior - drug effects
Tremor - chemically induced
Tremor - prevention & control
Tyramine - pharmacology
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Summary:The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors (50%) with negligible PEA-induced stereotypes (20%). Additionally, it did not produce a significant increase in the tyramine pressor effects. These results suggest that the dichloromethane fraction of A. catechu nut primarily elevates serotonin levels (probably via monoamine oxidase A inhibition) and does not induce cheese effect.
ISSN:1011-601X