Impact of Gender on the Prognosis of Patients With Nonvalvular Atrial Fibrillation

Treatment guidelines for atrial fibrillation (AF) used in Western countries describe female gender as a risk factor for thromboembolic events in patients with nonvalvular AF (NVAF). The present study aimed to determine the impact of gender on prognosis of Japanese patients with NVAF. A subanalysis o...

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Bibliographic Details
Published in:The American journal of cardiology 2014-03, Vol.113 (6), p.957-962
Main Authors: Inoue, Hiroshi, MD, Atarashi, Hirotsugu, MD, Okumura, Ken, MD, Yamashita, Takeshi, MD, Origasa, Hideki, PhD, Kumagai, Naoko, MS, Sakurai, Masayuki, MD, Kawamura, Yuichiro, MD, Kubota, Isao, MD, Matsumoto, Kazuo, MD, Kaneko, Yoshiaki, MD, Ogawa, Satoshi, MD, Aizawa, Yoshifusa, MD, Chinushi, Masaomi, MD, Kodama, Itsuo, MD, Watanabe, Eiichi, MD, Koretsune, Yukihiro, MD, Okuyama, Yuji, MD, Shimizu, Akihiko, MD, Igawa, Osamu, MD, Bando, Shigenobu, MD, Fukatani, Masahiko, MD, Saikawa, Tetsunori, MD, Chishaki, Akiko, MD
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - complications
Atrial Fibrillation - epidemiology
Cardiac arrhythmia
Cardiovascular
Female
Follow-Up Studies
Health risk assessment
Humans
Japan - epidemiology
Male
Men
Mortality
Older people
Prevalence
Prognosis
Retrospective Studies
Risk Assessment - methods
Risk Factors
Sex Distribution
Sex Factors
Stroke
Stroke - epidemiology
Stroke - etiology
Survival Rate - trends
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Summary:Treatment guidelines for atrial fibrillation (AF) used in Western countries describe female gender as a risk factor for thromboembolic events in patients with nonvalvular AF (NVAF). The present study aimed to determine the impact of gender on prognosis of Japanese patients with NVAF. A subanalysis of 7,406 patients with NVAF (mean age 70 years) who were followed-up prospectively for 2 years was performed using data from the J-RHYTHM registry. The primary end points were thromboembolic events, major hemorrhaging, total mortality, and cardiovascular mortality. Compared with male subjects (n = 5,241), female subjects (n = 2,165) were older and displayed greater prevalences of paroxysmal AF, heart failure, and hypertension but less prevalences of diabetes, previous cerebral infarction, and coronary artery disease. Male and female patients had mean CHADS2 (Congestive heart failure, Hypertension, Age of 75 years or more, Diabetes mellitus and prior Stroke or transient ischemic attack) scores of 1.6 and 1.8, respectively (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2013.11.057