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The depth of post-treatment perirectal tissue invasion is a predictor of outcome in patients with clinical T3N1M0 rectal cancer treated with neoadjuvant chemoradiation followed by surgical resection

Abstract Background To determine if patients with clinical stage III rectal cancer treated with neoadjuvant chemoradiotherapy (CRT) and surgery have an improved survival when the response to treatment results in a pathologic T3 tumor with a microscopic focus (≤5 mm) compared with a larger (>5 mm)...

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Published in:The American journal of surgery 2014-03, Vol.207 (3), p.357-360
Main Authors: Brandt, Whitney S., B.S, Yong, Sherri, M.D, Abood, Gerard, M.D., M.S, Micetich, Kenneth, M.D, Walther, Ashley, M.D, Shoup, Margo, M.D., F.A.C.S
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cited_by cdi_FETCH-LOGICAL-c448t-dfb783a3c895cfcfd2b99b685d4e46e8bec926656132f6ef6d163fdf7d70d5a13
cites cdi_FETCH-LOGICAL-c448t-dfb783a3c895cfcfd2b99b685d4e46e8bec926656132f6ef6d163fdf7d70d5a13
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container_title The American journal of surgery
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creator Brandt, Whitney S., B.S
Yong, Sherri, M.D
Abood, Gerard, M.D., M.S
Micetich, Kenneth, M.D
Walther, Ashley, M.D
Shoup, Margo, M.D., F.A.C.S
description Abstract Background To determine if patients with clinical stage III rectal cancer treated with neoadjuvant chemoradiotherapy (CRT) and surgery have an improved survival when the response to treatment results in a pathologic T3 tumor with a microscopic focus (≤5 mm) compared with a larger (>5 mm) invasion of the perirectal tissue. Methods A retrospective review was conducted of 56 consecutive patients clinically diagnosed as T3N1M0 rectal cancer before treatment, who completed neoadjuvant CRT followed by surgical resection. Those with residual pathologic T3 disease ( n = 28) were analyzed separately. Clinicopathologic data including T stage, lymph node status, k-ras status, and differentiation were reviewed. Results Among all 56 patients, there was no identified predictor of survival following neoadjuvant CRT and surgery. Among those with residual T3 disease, tumors extending >5 mm invasion into the perirectal tissue were associated with a higher risk of recurrence (50% vs 17%) and worse overall survival (4.3 vs 6.8 years, P = .015) when compared to tumors with ≤5 mm invasion into the perirectal tissue. Conclusion The depth of residual T3 tumor invasion into the perirectal tissue correlates with recurrence and overall survival in patients who underwent neoadjuvant therapy followed by surgical resection for clinically staged T3N1M0 rectal cancer.
doi_str_mv 10.1016/j.amjsurg.2013.09.011
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Methods A retrospective review was conducted of 56 consecutive patients clinically diagnosed as T3N1M0 rectal cancer before treatment, who completed neoadjuvant CRT followed by surgical resection. Those with residual pathologic T3 disease ( n = 28) were analyzed separately. Clinicopathologic data including T stage, lymph node status, k-ras status, and differentiation were reviewed. Results Among all 56 patients, there was no identified predictor of survival following neoadjuvant CRT and surgery. Among those with residual T3 disease, tumors extending &gt;5 mm invasion into the perirectal tissue were associated with a higher risk of recurrence (50% vs 17%) and worse overall survival (4.3 vs 6.8 years, P = .015) when compared to tumors with ≤5 mm invasion into the perirectal tissue. Conclusion The depth of residual T3 tumor invasion into the perirectal tissue correlates with recurrence and overall survival in patients who underwent neoadjuvant therapy followed by surgical resection for clinically staged T3N1M0 rectal cancer.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2013.09.011</identifier><identifier>PMID: 24456833</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abdomen ; Adult ; Aged ; Aged, 80 and over ; Cancer therapies ; Chemoradiotherapy, Adjuvant ; Chemotherapy ; Colorectal cancer ; Confidence intervals ; Female ; Humans ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Neoadjuvant therapy ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Postoperative period ; Prognosis ; Rectal cancer ; Rectal Neoplasms - mortality ; Rectal Neoplasms - pathology ; Rectal Neoplasms - surgery ; Rectal Neoplasms - therapy ; Rectal surgery ; Retrospective Studies ; Statistical analysis ; Surgery ; Survival Analysis ; Treatment Outcome ; Tumors</subject><ispartof>The American journal of surgery, 2014-03, Vol.207 (3), p.357-360</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. 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Methods A retrospective review was conducted of 56 consecutive patients clinically diagnosed as T3N1M0 rectal cancer before treatment, who completed neoadjuvant CRT followed by surgical resection. Those with residual pathologic T3 disease ( n = 28) were analyzed separately. Clinicopathologic data including T stage, lymph node status, k-ras status, and differentiation were reviewed. Results Among all 56 patients, there was no identified predictor of survival following neoadjuvant CRT and surgery. Among those with residual T3 disease, tumors extending &gt;5 mm invasion into the perirectal tissue were associated with a higher risk of recurrence (50% vs 17%) and worse overall survival (4.3 vs 6.8 years, P = .015) when compared to tumors with ≤5 mm invasion into the perirectal tissue. 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Methods A retrospective review was conducted of 56 consecutive patients clinically diagnosed as T3N1M0 rectal cancer before treatment, who completed neoadjuvant CRT followed by surgical resection. Those with residual pathologic T3 disease ( n = 28) were analyzed separately. Clinicopathologic data including T stage, lymph node status, k-ras status, and differentiation were reviewed. Results Among all 56 patients, there was no identified predictor of survival following neoadjuvant CRT and surgery. Among those with residual T3 disease, tumors extending &gt;5 mm invasion into the perirectal tissue were associated with a higher risk of recurrence (50% vs 17%) and worse overall survival (4.3 vs 6.8 years, P = .015) when compared to tumors with ≤5 mm invasion into the perirectal tissue. Conclusion The depth of residual T3 tumor invasion into the perirectal tissue correlates with recurrence and overall survival in patients who underwent neoadjuvant therapy followed by surgical resection for clinically staged T3N1M0 rectal cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24456833</pmid><doi>10.1016/j.amjsurg.2013.09.011</doi><tpages>4</tpages></addata></record>
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source ScienceDirect Journals
subjects Abdomen
Adult
Aged
Aged, 80 and over
Cancer therapies
Chemoradiotherapy, Adjuvant
Chemotherapy
Colorectal cancer
Confidence intervals
Female
Humans
Male
Medical prognosis
Metastasis
Middle Aged
Neoadjuvant therapy
Neoplasm Invasiveness
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Postoperative period
Prognosis
Rectal cancer
Rectal Neoplasms - mortality
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Rectal Neoplasms - therapy
Rectal surgery
Retrospective Studies
Statistical analysis
Surgery
Survival Analysis
Treatment Outcome
Tumors
title The depth of post-treatment perirectal tissue invasion is a predictor of outcome in patients with clinical T3N1M0 rectal cancer treated with neoadjuvant chemoradiation followed by surgical resection
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