Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: Role of 67-kDa laminin receptor and hydrogen peroxide

•Green tea polyphenols potentiate the action of brain-derived neurotrophic factor.•Epigallocatechin-3-gallate mediates this effect along with other polyphenols.•This potentiation is mediated by cell-surface associated 67kDa laminin receptor.•Endogenous hydrogen peroxide mediates potentiation induced...

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Published in:Biochemical and biophysical research communications 2014-02, Vol.445 (1), p.218-224
Main Authors: Gundimeda, Usha, McNeill, Thomas H., Fan, Tiffany K., Deng, Ronald, Rayudu, David, Chen, Zachary, Cadenas, Enrique, Gopalakrishna, Rayudu
Format: Article
Language:English
Subjects:
67-kDa laminin receptor
Animals
Antioxidants - pharmacology
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - pharmacology
Catechin - analogs & derivatives
Catechin - pharmacology
Dose-Response Relationship, Drug
Drug Synergism
Epigallocatechin-3-gallate
Green tea polyphenol
Hydrogen peroxide
Hydrogen Peroxide - metabolism
Hydrogen Peroxide - pharmacology
Molecular Weight
Neurites - drug effects
Neurites - physiology
Neuritogenesis
Oxidants - metabolism
Oxidants - pharmacology
PC12 Cells
Polyphenols - pharmacology
Rats
Receptor, trkB - genetics
Receptor, trkB - metabolism
Receptors, Laminin - chemistry
Receptors, Laminin - metabolism
Receptors, Laminin - physiology
Tea - chemistry
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Summary:•Green tea polyphenols potentiate the action of brain-derived neurotrophic factor.•Epigallocatechin-3-gallate mediates this effect along with other polyphenols.•This potentiation is mediated by cell-surface associated 67kDa laminin receptor.•Endogenous hydrogen peroxide mediates potentiation induced by these polyphenols.•Exogenous hydrogen peroxide mimics green tea polyphenols in inducing this effect. Delivery of optimal amounts of brain-derived neurotrophic factor (BDNF) to regions of the brain affected by neurodegenerative diseases is a daunting task. Using natural products with neuroprotective properties, such as green tea polyphenols, would be a highly useful complementary approach for inexpensive long-term treatment of these diseases. In this study, we used PC12(TrkB) cells which ectopically express TrkB, a high affinity receptor for BDNF. They differentiate and induce neurite outgrowth in response to BDNF. Using this model, we show for the first time that treatment with extremely low concentrations (
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2014.01.166