Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock

Boomer et al [5] reported extensive depletion of splenic CD4, CD8, and HLA-DR cells in patients dying of sepsis. [...]HLA-DR expression in monocytes has been proposed to be a reliable predictor of mortality in severe sepsis [6]. Boomer et al [5] reported extensive depletion of splenic CD4, CD8, and...

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Published in:Journal of critical care 2014-04, Vol.29 (2), p.307-309
Main Authors: Almansa, Raquel, PhD, Tamayo, Eduardo, MD, PhD, Heredia, María, MD, PhD, Gutierrez, Sandra, MD, Ruiz, Patricia, MD, Alvarez, Elisa, MD, Gomez-Sanchez, Esther, MD, PhD, Andaluz-Ojeda, David, MD, Ceña, Rafael, BSc, Rico, Lucia, MLT, Iglesias, Verónica, MLT, Gomez-Herreras, Jose Ignacio, MD, PhD, Bermejo-Martin, Jesús F., MD, PhD, Ceña, Rafael, Rico, Lucia, Iglesias, Verónica, Gomez-Herreras, Jose Ignacio, Bermejo-Martin, Jesús F
Format: Article
Language:English
Subjects:
Case-Control Studies
Critical Care
Data analysis
Gene expression
Gene Expression Profiling
Genomes
Humans
Immune system
Immunoglobulin G - biosynthesis
Immunoglobulin G - genetics
Immunoglobulins
Immunoglobulins - genetics
Mortality
Patients
Pediatrics
Sepsis
Shock, Septic - genetics
Shock, Septic - immunology
Shock, Septic - mortality
Software
Systemic Inflammatory Response Syndrome - genetics
Transcriptome
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Summary:Boomer et al [5] reported extensive depletion of splenic CD4, CD8, and HLA-DR cells in patients dying of sepsis. [...]HLA-DR expression in monocytes has been proposed to be a reliable predictor of mortality in severe sepsis [6]. Boomer et al [5] reported extensive depletion of splenic CD4, CD8, and HLA-DR cells in patients dying of sepsis. [...]HLA-DR expression in monocytes has been proposed to be a reliable predictor of mortality in severe sepsis [6]. [...]defective expression of genes playing critical roles in T helper/B-cell activation and immunoglobulin isotype switching could contribute to explain the low levels of IgG observed in patients dying of SS.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2013.11.020