Urinary type IV collagen as a predictor for the incidence of microalbuminuria in young patients with Type 1 diabetes

Aims To clarify whether urinary type IV collagen‐to‐creatinine ratio is a predictor for the incidence of microalbuminuria in patients with Type 1 diabetes. Methods A longitudinal observational cohort study was conducted; the subjects included normoalbuminuric patients diagnosed with Type 1 diabetes...

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Bibliographic Details
Published in:Diabetic medicine 2014-02, Vol.31 (2), p.213-218
Main Authors: Morita, M., Hanai, K., Uchigata, Y.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Albuminuria - diagnosis
Albuminuria - epidemiology
Albuminuria - etiology
Biological and medical sciences
Biomarkers - urine
Cats
Collagen
Collagen Type IV - urine
Diabetes
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - metabolism
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Glycated Hemoglobin A - metabolism
Humans
Incidence
Longitudinal Studies
Male
Medical sciences
Prognosis
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Young Adult
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Summary:Aims To clarify whether urinary type IV collagen‐to‐creatinine ratio is a predictor for the incidence of microalbuminuria in patients with Type 1 diabetes. Methods A longitudinal observational cohort study was conducted; the subjects included normoalbuminuric patients diagnosed with Type 1 diabetes before the age of 30 years and who were less than 40 years old at the start of the observation. In total, 225 patients were enrolled (age, mean ± SD: 25 ± 5 years; male: 32.9%). The endpoint was the incidence of microalbuminuria, defined as 30 mg/g Cr ≤ urinary albumin‐to‐creatinine ratio < 300 mg/g Cr. Patients were divided into two groups based on the median of urinary type IV collagen‐to‐creatinine ratio levels. Results During the median follow‐up period of 8.8 years (range 1.0–12.8 years), 13 patients with high urinary type IV collagen‐to‐creatinine ratio progressed to microalbuminuria. Meanwhile, only one patient with low urinary type IV collagen‐to‐creatinine ratio reached the endpoint. Kaplan–Meier estimates for the time to reach the endpoint were significantly faster for patients with a high ratio than for those with a low ratio (log‐rank test, P 
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.12317