Effectiveness of Novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole Derivatives Against Promastigotes and Amastigotes of Leishmania amazonensis

In this research, a series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania...

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Published in:Chemical biology & drug design 2014-03, Vol.83 (3), p.272-277
Main Authors: dos Santos Faiões, Viviane, Leon, Leonor L., Canto-Cavalheiro, Marilene M., Torres-Santos, Eduardo C., Bernardino, Alice M. R., Vegi, Percilene F., dos Santos, Maurício S.
Format: Article
Language:English
Subjects:
Animals
antileishmanial activity
Antiprotozoal Agents - chemical synthesis
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - pharmacology
Cell Line
Cell Survival - drug effects
Leishmania - drug effects
Leishmania amazonensis
Mice
Mice, Inbred BALB C
tetrazole derivatives
Tetrazoles - chemical synthesis
Tetrazoles - chemistry
Tetrazoles - pharmacology
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Summary:In this research, a series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI). A series of substituted 5‐(5‐amino‐1‐aryl‐1H‐pyrazol‐4‐yl)‐1H‐tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).
ISSN:1747-0277
1747-0285
DOI:10.1111/cbdd.12235