Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer

BACKGROUND The authors hypothesized that circulating tumor cells (CTCs) in patients with gastric cancer are associated with prognosis and disease recurrence. In this study, they evaluated CTCs in gastric cancer and clarified the clinical impact of CTCs. METHODS In total, 265 consecutive patients wit...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 2013-11, Vol.119 (22), p.3984-3991
Main Authors: Uenosono, Yoshikazu, Arigami, Takaaki, Kozono, Tsutomu, Yanagita, Shigehiro, Hagihara, Takahiko, Haraguchi, Naoto, Matsushita, Daisuke, Hirata, Munetsugu, Arima, Hideo, Funasako, Yawara, Kijima, Yuko, Nakajo, Akihiro, Okumura, Hiroshi, Ishigami, Sumiya, Hokita, Shuichi, Ueno, Shinichi, Natsugoe, Shoji
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - blood
Cell Line, Tumor
circulating tumor cells
Disease-Free Survival
Female
gastric cancer
Gastroenterology. Liver. Pancreas. Abdomen
hematogenous recurrence
Humans
Male
Medical sciences
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Neoplastic Cells, Circulating - pathology
peritoneal dissemination
prognosis
Stomach Neoplasms - blood
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND The authors hypothesized that circulating tumor cells (CTCs) in patients with gastric cancer are associated with prognosis and disease recurrence. In this study, they evaluated CTCs in gastric cancer and clarified the clinical impact of CTCs. METHODS In total, 265 consecutive patients with gastric cancer were enrolled. Fourteen patients were excluded from the analysis, including 12 patients who another cancer and 2 patients who refused the treatment. The remaining 251 patients were divided into 2 groups: 148 patients who underwent gastrectomy (the resection group) and 103 patients who did not undergo gastrectomy (the nonresectable group). Peripheral blood samples were collected before gastrectomy or chemotherapy. A proprietary test for capturing, identifying, and counting CTCs in blood was used for the isolation and enumeration of CTCs. RESULTS CTCs were detected in 16 patients (10.8%) from the resection group and in 62 patients (60.2%) from the nonresectable group. The overall survival rate for the entire cohort was significantly lower in patients with CTCs than in those without CTCs (P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.28309