A pyrene derivative for Hg(2+) -selective fluorescent sensing and its application in in vivo imaging

An Hg(2+) -selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490 nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichm...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2014-03, Vol.9 (3), p.744-748
Main Authors: Wang, Guang Ke, Mi, Qi Li, Zhao, Li Yun, Hu, Jun Jie, Guo, Lin E, Zou, Xiao Ju, Liu, Bo, Xie, Xiao Guang, Zhang, Jun Feng, Zhao, Qi Hua, Zhou, Ying
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans - anatomy & histology
Caenorhabditis elegans - chemistry
Caenorhabditis elegans - metabolism
Fluorescent Dyes - analysis
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Mercury - analysis
Molecular Structure
Pyrenes - chemical synthesis
Pyrenes - chemistry
Zebrafish - anatomy & histology
Zebrafish - metabolism
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Summary:An Hg(2+) -selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490 nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichment and distribution of mercury in the nervous system, digestive system, and reproductive system of Caenorhabditis elegans, as well as the organs of zebrafish.
ISSN:1861-471X
DOI:10.1002/asia.201301123