Induced Adaptation of Bacillus sp. to Antimicrobial Nanosilver

The natural ability of Bacillus sp. to adapt to nanosilver cytotoxicity upon prolonged exposure is reported for the first time. The combined adaptive effects of nanosilver resistance and enhanced growth are induced under various intensities of nanosilver‐stimulated cellular oxidative stress, ranging...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2013-11, Vol.9 (21), p.3554-3560
Main Authors: Gunawan, Cindy, Teoh, Wey Yang, Marquis, Christopher P., Amal, Rose
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antimicrobial resistance
Bacillus
Bacillus - drug effects
Bacillus - physiology
cellular oxidative stress
Drug Resistance, Microbial
induced adaptation
Metal Nanoparticles
Microbial Sensitivity Tests
Microscopy, Electron, Transmission
Nanotechnology
Silver - chemistry
Silver - pharmacology
silver nanoparticles
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Summary:The natural ability of Bacillus sp. to adapt to nanosilver cytotoxicity upon prolonged exposure is reported for the first time. The combined adaptive effects of nanosilver resistance and enhanced growth are induced under various intensities of nanosilver‐stimulated cellular oxidative stress, ranging from only minimal cellular redox imbalance to the lethal levels of cellular ROS stimulation. An important implication of the present work is that such adaptive effects lead to the ultimate domination of nanosilver‐resistant Bacillus sp. in the microbiota, to which nanosilver cytotoxicity is continuously applied.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201300761