Early Recurrence After Liver Resection for Colorectal Metastases: Risk Factors, Prognosis, and Treatment. A LiverMetSurvey-Based Study of 6,025 Patients

Purpose The aims of this study were to assess the risk of early recurrence after liver resection for colorectal metastases (CRLM) and its prognostic value; identify early recurrence predictive factors; clarify the effect of perioperative chemotherapy on its occurrence; and elucidate the best early r...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2014-04, Vol.21 (4), p.1276-1286
Main Authors: Viganò, Luca, Capussotti, Lorenzo, Lapointe, Réal, Barroso, Eduardo, Hubert, Catherine, Giuliante, Felice, Ijzermans, Jan N. M., Mirza, Darius F., Elias, Dominique, Adam, René
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Combined Modality Therapy
Female
Follow-Up Studies
Hepatectomy - adverse effects
Hepatobiliary Tumors
Humans
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Male
Medicine
Medicine & Public Health
Neoplasm Metastasis
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - etiology
Neoplasm Recurrence, Local - mortality
Neoplasm Staging
Oncology
Prognosis
Surgery
Surgical Oncology
Survival Rate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The aims of this study were to assess the risk of early recurrence after liver resection for colorectal metastases (CRLM) and its prognostic value; identify early recurrence predictive factors; clarify the effect of perioperative chemotherapy on its occurrence; and elucidate the best early recurrence management. Methods Patients of the LiverMetSurvey registry who underwent complete liver resection (R0/R1) between 1998 and 2009 were reviewed. Early recurrence was defined as any recurrence that occurred within 6 months after resection. Results A total of 6,025 patients were included; 2,734 (45.4 %) had recurrence, including 639 (10.6 %) early recurrences. Early recurrence was mainly hepatic (59.5 vs. 54.4 % for late recurrences; p  = 0.023). Independent risk factors of early recurrence were: T3–4 primary tumor ( p  = 0.0002); synchronous CRLM ( p  = 0.0001); >3 CRLM ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-013-3421-8