A study of adaptation mechanisms based on ABR recorded at high stimulation rate

Highlights • The fast and slow adaptation mechanisms are studied for the first time in humans through the separated responses methodology. • Both fast and slow mechanisms of adaptation are present in all subjects, which is consistent with previous animal studies based on spike rate. • The morphology...

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Bibliographic Details
Published in:Clinical neurophysiology 2014-04, Vol.125 (4), p.805-813
Main Authors: Valderrama, Joaquin T, de la Torre, Angel, Alvarez, Isaac, Segura, Jose Carlos, Thornton, A. Roger D, Sainz, Manuel, Vargas, Jose Luis
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Adaptation
Adaptation, Physiological - physiology
Adult
Auditory Brainstem Response (ABR)
Auditory Threshold - physiology
Electroencephalography
Evoked potentials
Evoked Potentials, Auditory, Brain Stem - physiology
Female
Humans
Interstimulus interval (ISI)
Male
Middle Aged
Neurology
Randomized stimulation and averaging (RSA)
Reaction Time - physiology
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Summary:Highlights • The fast and slow adaptation mechanisms are studied for the first time in humans through the separated responses methodology. • Both fast and slow mechanisms of adaptation are present in all subjects, which is consistent with previous animal studies based on spike rate. • The morphology of the ABR is not only influenced by the stimulation rate, but also by the distribution of the jitter, and by the sequencing of stimuli.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2013.06.190