Ruthenium-Catalyzed Regio- and Enantioselective Allylic Amination of Racemic 1‑Arylallyl Esters

The regio- and enantioselective allylic amination of racemic monosubstituted allylic esters, such as 1-arylallyl acetates, with cyclic secondary amines has been accomplished. The RuCl3/(S,S)-ip-pybox catalyst system has effectively catalyzed the reaction to afford the enantiomerically enriched branc...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2014-03, Vol.16 (5), p.1470-1473
Main Authors: Kawatsura, Motoi, Uchida, Kenta, Terasaki, Shou, Tsuji, Hiroaki, Minakawa, Maki, Itoh, Toshiyuki
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The regio- and enantioselective allylic amination of racemic monosubstituted allylic esters, such as 1-arylallyl acetates, with cyclic secondary amines has been accomplished. The RuCl3/(S,S)-ip-pybox catalyst system has effectively catalyzed the reaction to afford the enantiomerically enriched branch-type allylic amines with perfect regioselectivity and high enantioselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol5002768