Efficacy of florfenicol injection in the treatment of Mycoplasma hyopneumoniae induced respiratory disease in pigs

• Published in: The veterinary journal (1997) 2012-12, Vol.194 (3), p.420-422
• Main Authors: Del Pozo Sacristán, R., Thiry, J., Vranckx, K., López Rodríguez, A., Chiers, K., Haesebrouck, F., Thomas, E., Maes, D.
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; average daily gain; feed conversion; Florfenicol; Injections, Intramuscular - veterinary; intramuscular injection; mortality; Mycoplasma hyopneumoniae; Mycoplasma hyopneumoniae - genetics; Mycoplasma hyopneumoniae - isolation & purification; Mycoplasma hyopneumoniae - metabolism; piglets; Pigs; Pneumonia of Swine, Mycoplasmal - drug therapy; Polymerase Chain Reaction - veterinary; respiratory tract diseases; Swine; Thiamphenicol - analogs & derivatives; Thiamphenicol - therapeutic use; Treatment; virulence
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2012.04.015

This study investigated the efficacy of a single intramuscular injection of a new formulation of florfenicol to treat clinical respiratory disease following experimental Mycoplasma hyopneumoniae infection. M. hyopneumoniae-free piglets were allocated to three groups, namely, a treatment group (TG) and a positive control group (PCG), which were both inoculated endotracheally with a highly virulent isolate of M. hyopneumoniae, and a negative control group. At the onset of clinical disease, the TG received a single injection of florfenicol (30mg/kg). All pigs were euthanased 4weeks post-infection. Clinical symptoms were significantly reduced in the TG in comparison with the PCG. Average daily gain, feed conversion ratio, mortality and lung lesions were improved in the TG compared to the PCG, but the differences were not statistically significant.