Protective effect of Spirulina platensis enriched in phenolic compounds against hepatotoxicity induced by CCl4

•The hepatoprotective effect of Spirulina platensis enriched in phenolics (SP2) was examined.•SP2 was more potent than S. platensis with low amounts of phenolics (SP1).•The CCl4-induced increases in ALT and AST were attenuated by SP2.•The hepatic lessions were counteracted more effectively by SP2 pr...

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Bibliographic Details
Published in:Food chemistry 2013-12, Vol.141 (3), p.1972-1979
Main Authors: Kepekçi, Remziye Aysun, Polat, Sait, Çelik, Ahmet, Bayat, Nuray, Saygideger, Saadet Demirörs
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Animals
Antioxidant activity
Antioxidants - metabolism
Aspartate Aminotransferases - metabolism
Biological and medical sciences
Carbon Tetrachloride - toxicity
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - enzymology
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - metabolism
Food toxicology
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Hepatoprotectivity
Humans
Liver - drug effects
Liver - enzymology
Liver - metabolism
Male
Malondialdehyde - metabolism
Medical sciences
Phenolic compounds
Phenols - administration & dosage
Protective Agents - administration & dosage
Rats
Rats, Wistar
Secondary metabolites
Spirulina - chemistry
Spirulina platensis
Superoxide Dismutase - metabolism
Toxicology
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Summary:•The hepatoprotective effect of Spirulina platensis enriched in phenolics (SP2) was examined.•SP2 was more potent than S. platensis with low amounts of phenolics (SP1).•The CCl4-induced increases in ALT and AST were attenuated by SP2.•The hepatic lessions were counteracted more effectively by SP2 pretreatment.•SP2 pretreatment also showed more improvement in ultrastructure of livers of rats. Phenolic compounds make up the major secondary metabolites with high pharmaceutical potential. Microalgae were reported to contain low amounts of phenolic compounds. The present study aimed to investigate the hepatoprotective potential of biomass of Spirulina platensis enriched in phenolic compounds. The protective effects of the biomass of S. platensis with low amounts of phenolics (SP1) and with high amounts of phenolics (SP2) against CCl4-induced acute hepatotoxicity were evaluated in rats. The increased levels of ALT, AST and MDA along with decreased activities of SOD and CAT were significantly (p
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2013.04.107