An Unconventional Role of BMP-Smad1 Signaling in DNA Damage Response: A Mechanism for Tumor Suppression

ABSTRACT The genome is under constant attack by self‐produced reactive oxygen species and genotoxic reagents in the environment. Cells have evolved a DNA damage response (DDR) system to sense DNA damage, to halt cell cycle progression and repair the lesions, or to induce apoptosis if encountering ir...

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Published in:Journal of cellular biochemistry 2014-03, Vol.115 (3), p.450-456
Main Authors: Liu, Huijuan, Bao, Dandan, Xia, Xuechun, Chau, Jenny Fung Ling, Li, Baojie
Format: Article
Language:English
Subjects:
Animals
Apoptosis - genetics
Bone Morphogenetic Proteins - genetics
Bone Morphogenetic Proteins - metabolism
Bone Remodeling - genetics
DNA Damage - genetics
DNA Repair - genetics
Gene Expression Regulation, Developmental
Humans
Mice
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Reactive Oxygen Species - metabolism
Signal Transduction - genetics
Smad1 Protein - biosynthesis
Smad1 Protein - genetics
Smad1 Protein - metabolism
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Summary:ABSTRACT The genome is under constant attack by self‐produced reactive oxygen species and genotoxic reagents in the environment. Cells have evolved a DNA damage response (DDR) system to sense DNA damage, to halt cell cycle progression and repair the lesions, or to induce apoptosis if encountering irreparable damage. The best studied DDR pathways are the PIKK‐p53 and PIKK‐Chk1/2. Mutations in these genes encoding DDR molecules usually lead to genome instability and tumorigenesis. It is worth noting that there exist unconventional pathways that facilitate the canonical pathways or take over in the absence of the canonical pathways in DDR. This review will summarize on several unconventional pathways that participate in DDR with an emphasis on the BMP‐Smad1 pathway, a known regulator of mouse development and bone remodeling. J. Cell. Biochem. 115: 450–456, 2014. © 2013 Wiley Periodicals, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.24698