An Unconventional Role of BMP-Smad1 Signaling in DNA Damage Response: A Mechanism for Tumor Suppression

• Published in: Journal of cellular biochemistry 2014-03, Vol.115 (3), p.450-456
• Main Authors: Liu, Huijuan, Bao, Dandan, Xia, Xuechun, Chau, Jenny Fung Ling, Li, Baojie
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis - genetics; Bone Morphogenetic Proteins - genetics; Bone Morphogenetic Proteins - metabolism; Bone Remodeling - genetics; DNA Damage - genetics; DNA Repair - genetics; Gene Expression Regulation, Developmental; Humans; Mice; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Reactive Oxygen Species - metabolism; Signal Transduction - genetics; Smad1 Protein - biosynthesis; Smad1 Protein - genetics; Smad1 Protein - metabolism
• ISSN: 0730-2312; 1097-4644
• DOI: 10.1002/jcb.24698

ABSTRACT The genome is under constant attack by self‐produced reactive oxygen species and genotoxic reagents in the environment. Cells have evolved a DNA damage response (DDR) system to sense DNA damage, to halt cell cycle progression and repair the lesions, or to induce apoptosis if encountering irreparable damage. The best studied DDR pathways are the PIKK‐p53 and PIKK‐Chk1/2. Mutations in these genes encoding DDR molecules usually lead to genome instability and tumorigenesis. It is worth noting that there exist unconventional pathways that facilitate the canonical pathways or take over in the absence of the canonical pathways in DDR. This review will summarize on several unconventional pathways that participate in DDR with an emphasis on the BMP‐Smad1 pathway, a known regulator of mouse development and bone remodeling. J. Cell. Biochem. 115: 450–456, 2014. © 2013 Wiley Periodicals, Inc.