Feline sporotrichosis: Histopathological profile of cutaneous lesions and their correlation with clinical presentation

Abstract Cutaneous lesions of feline sporotrichosis show high fungal load and are associated with severe disease and elevated zoonotic potential. The present study describes the histopathology and fungal load of the lesions in different clinical presentations of feline sporotrichosis. Cats with spor...

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Bibliographic Details
Published in:Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2013-07, Vol.36 (4), p.425-432
Main Authors: Miranda, Luisa H.M, Conceição-Silva, Fátima, Quintella, Leonardo P, Kuraiem, Bianca P, Pereira, Sandro A, Schubach, Tânia M.P
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Biopsy - veterinary
Brazil
Cat
Cat Diseases - microbiology
Cat Diseases - pathology
Cats
Chi-Square Distribution
Cross-Sectional Studies
Female
Histocytochemistry - veterinary
Histopathology
Infectious Disease
Male
Skin
Sporothrix - isolation & purification
Sporothrix schenckii
Sporotrichosis
Sporotrichosis - microbiology
Sporotrichosis - pathology
Sporotrichosis - veterinary
Zoonoses - microbiology
Zoonoses - pathology
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Summary:Abstract Cutaneous lesions of feline sporotrichosis show high fungal load and are associated with severe disease and elevated zoonotic potential. The present study describes the histopathology and fungal load of the lesions in different clinical presentations of feline sporotrichosis. Cats with sporotrichosis were separated into groups L1, L2 and L3 (lesions in one, two and three or more locations, respectively) and subjected to skin biopsies for histopathology. Eighty-six cats were included in the study. Lesions were suppurative granulomatous in 84 cases and poorly formed granulomas were predominant. The well-formed granulomas were associated with group L1. The high fungal load was predominant in group L3 and in poorly formed granuloma cases and did not occur in well-formed granulomas cases. The good general condition was associated with low fungal load. These findings suggest that the fungal load control in animals with more localized lesions and well-organized response is linked with the improvement in the outcome of infected cats.
ISSN:0147-9571
1878-1667
DOI:10.1016/j.cimid.2013.03.005