Disseminated Infection due to Saksenaea vasiformis Secondary to Cutaneous Mucormycosis

Mucormycosis is an uncommon opportunistic fungal infection caused by Zygomycetes. It usually affects immunocompromised, diabetic and trauma patients with infected wounds. We report a case of disseminated infection secondary to facial cutaneous mucormycosis caused by Saksenaea vasiformis in a diabeti...

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Bibliographic Details
Published in:Mycopathologia (1975) 2014-02, Vol.177 (1-2), p.97-101
Main Authors: Gómez-Camarasa, Cristina, Rojo-Martín, María Dolores, Miranda-Casas, Consuelo, Alastruey-Izquierdo, Ana, Aliaga-Martínez, Luis, Labrador-Molina, José Miguel, Navarro-Marí, José María
Format: Article
Language:English
Subjects:
Amphotericin B
Amphotericin B - therapeutic use
Anti-Bacterial Agents - therapeutic use
Antifungal Agents - therapeutic use
Antiparasitic agents
Biomedical and Life Sciences
Cellulitis
Craniocerebral Trauma
Debridement
Dermatomycoses - drug therapy
Dermatomycoses - microbiology
Development and progression
Diabetes
Diabetes Complications - microbiology
Diabetes Mellitus - microbiology
Diabetics
Eukaryotic Microbiology
Fungi
Health aspects
Humans
Immunocompetence
Immunocompromised Host
Infection
Infections
Life Sciences
Male
Medical Microbiology
Microbial Ecology
Microbiology
Middle Aged
Molecular Sequence Data
Mucorales - classification
Mucorales - drug effects
Mucormycosis
Mucormycosis - drug therapy
Mucormycosis - microbiology
NMR
Nuclear magnetic resonance
Patients
Plant Sciences
Saksenaea vasiformis
Sepsis - microbiology
Trauma
Zygomycetes
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Summary:Mucormycosis is an uncommon opportunistic fungal infection caused by Zygomycetes. It usually affects immunocompromised, diabetic and trauma patients with infected wounds. We report a case of disseminated infection secondary to facial cutaneous mucormycosis caused by Saksenaea vasiformis in a diabetic patient who had a farming accident causing him severe head injury. The patient was treated with a combination of surgical debridement and antifungal therapy with liposomal amphotericin B, but he had a slow and fatal outcome. In cases of tissue necrosis following trauma involving wound contact with soil (i.e., potential fungal contamination), testing for the presence of Zygomycetes fungi such as S. vasiformis in both immunocompetent and immunocompromised patients is crucial. The reason is that this infection usually has a rapid progression and may be fatal if appropriate treatment is not administered.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-013-9715-3