The role of serotonin in memory: interactions with neurotransmitters and downstream signaling

Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT 1–7 ), each with several subpopulations, have been identified for serotonin, which are different in terms of localizati...

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Bibliographic Details
Published in:Experimental brain research 2014-03, Vol.232 (3), p.723-738
Main Authors: Seyedabadi, Mohammad, Fakhfouri, Gohar, Ramezani, Vahid, Mehr, Shahram Ejtemaei, Rahimian, Reza
Format: Article
Language:English
Subjects:
Acids
Aging
Alzheimer's disease
Analysis
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brain research
Cognitive ability
Dopamine
Fundamental and applied biological sciences. Psychology
Humans
Kinases
Learning
Localization
Memory
Memory - physiology
Neurology
Neurosciences
Neurotransmitter Agents - metabolism
Physiological aspects
Proteins
Review
Serotonin
Serotonin - metabolism
Signal Transduction - physiology
Vertebrates: nervous system and sense organs
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Summary:Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT 1–7 ), each with several subpopulations, have been identified for serotonin, which are different in terms of localization and downstream signaling. Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years. A large body of evidence indicates the interplay between serotonergic transmission and other neurotransmitters including acetylcholine, dopamine, γ-aminobutyric acid (GABA) and glutamate, in the neurobiological control of learning and memory. In addition, there has been an alteration in the density of serotonergic receptors in aging and Alzheimer’s disease, and serotonin modulators are found to alter the process of amyloidogenesis and exert cognitive-enhancing properties. Here, we discuss the serotonin-induced modulation of various systems involved in mnesic function including cholinergic, dopaminergic, GABAergic, glutamatergic transmissions as well as amyloidogenesis and intracellular pathways.
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-013-3818-4