Toll-like receptor levels and caffeine responsiveness in rat pups during perinatal period

Infants born prematurely are prone to bronchopulmonary dysplasia which is a devastating form of chronic lung disease that develops in very low birth weight infants. Toll-like receptors (TLRs) are pattern recognition receptors that initiate innate immune responses. We tested TLR2, 4, and 9 levels in...

Full description

Saved in:
Bibliographic Details
Published in:Regulatory peptides 2013-03, Vol.182, p.41-44
Main Authors: Tunc, Turan, Aydemir, Gokhan, Karaoglu, Abdulbaki, Cekmez, Ferhat, Kul, Mustafa, Aydinoz, Secil, Babacan, Oguzhan, Yaman, Halil, Sarici, Serdar Umit
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Caffeine
Caffeine - pharmacology
Newborn lung
Rats
Rats, Sprague-Dawley
Toll-like receptor
Toll-Like Receptors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infants born prematurely are prone to bronchopulmonary dysplasia which is a devastating form of chronic lung disease that develops in very low birth weight infants. Toll-like receptors (TLRs) are pattern recognition receptors that initiate innate immune responses. We tested TLR2, 4, and 9 levels in the lungs of rat pups given caffeine at the first days of postnatal life. Twenty-four rat pups equally divided into three groups. The study group received caffeine immediately after birth for ten days. The levels of TLR9 were found significantly higher in study group than control groups. We conclude that the beneficial and anti-inflammatory effects of caffeine in the lungs of newborn rats may be due to increased TLR9 levels.
ISSN:0167-0115
1873-1686
DOI:10.1016/j.regpep.2012.12.016