Immuno-proteomic analysis of human immune responses to experimental Neisseria meningitidis outer membrane vesicle vaccines identifies potential cross-reactive antigens

Highlights • Adult volunteers vaccinated with experimental Neisseria meningitidis serogroup B vaccines elicit cross-bactericidal antibodies. • Immuno-proteomics on a heterologous meningococcal strain identifies potential targets of these cross-bactericidal antisera. • Increases in bactericidal activ...

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Bibliographic Details
Published in:Vaccine 2014-03, Vol.32 (11), p.1280-1286
Main Authors: Williams, Jeannette N, Weynants, Vincent, Poolman, Jan T, Heckels, John E, Christodoulides, Myron
Format: Article
Language:English
Subjects:
Allergy and Immunology
Analytical, structural and metabolic biochemistry
Antibodies, Bacterial - blood
Antigens, Bacterial - immunology
Applied microbiology
Bacterial Outer Membrane Proteins - immunology
Bacteriology
Biological and medical sciences
Biological properties
Clinical Trials, Phase I as Topic
Cross Reactions - immunology
Fundamental and applied biological sciences. Psychology
Genomes
Humans
Immuno-proteomics
Meningitis
Meningococcal Vaccines - immunology
Microbiology
Miscellaneous
Neisseria meningitidis
Neisseria meningitidis, Serogroup B
Outer membrane vesicle
Proteins
Proteome - immunology
Proteomics
Randomized Controlled Trials as Topic
Serum Bactericidal Antibody Assay
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Highlights • Adult volunteers vaccinated with experimental Neisseria meningitidis serogroup B vaccines elicit cross-bactericidal antibodies. • Immuno-proteomics on a heterologous meningococcal strain identifies potential targets of these cross-bactericidal antisera. • Increases in bactericidal activity against the heterologous strain correlates with immune-proteome blot reactivity. • Well-known antigens such as Rmp, Opa, porB and FpbA are identified within the immune-proteome. • Important novel antigens e.g. putative cell binding factor, exoployphosphatase and glutamyltranspeptidase are also identified.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.12.070