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Evaluation of urinary HURP mRNA as a marker for detection of bladder cancer: relation to bilharziasis
This study was carried out to assess the efficacy of urinary hepatoma up-regulated protein ( HURP ) RNA in bladder cancer diagnosis and its relation to bilharziasis. Voided urine samples and blood were collected from 344 consecutive participants: 211 patients diagnosed with bladder cancer, 71 patien...
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Published in: | Medical oncology (Northwood, London, England) London, England), 2014-02, Vol.31 (2), p.804-804, Article 804 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | This study was carried out to assess the efficacy of urinary hepatoma up-regulated protein (
HURP
) RNA in bladder cancer diagnosis and its relation to bilharziasis. Voided urine samples and blood were collected from 344 consecutive participants: 211 patients diagnosed with bladder cancer, 71 patients with benign urological disorders and 62 healthy volunteers. Serologic assessment of schistosomiasis antibody in sera, urine cytology and estimation of
HURP
RNA by reverse transcription polymerase chain reaction in urothelial cells was carried out in all samples.
HURP
RNA expression showed a significant difference among the three investigated groups. The best cutoff point for
HURP
RNA was determined as 0.0132 at 78.67 % sensitivity and 94 % specificity. The sensitivity of urine cytology was improved when combined with
HURP
RNA in detection of early stage (77.3 %), low grade (85.3 %) and bilharzial bladder cancer (78.1 %). Detection of urinary
HURP
RNA is a useful non-invasive test for early detection of bladder cancer and bilharzial bladder cancer and it improves sensitivity of urine cytology up to 91 %. |
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ISSN: | 1357-0560 1559-131X |
DOI: | 10.1007/s12032-013-0804-4 |