BK and JC virus: A review

Summary Polyomaviruses are ubiquitous, species-specific viruses belonging to the family Papovaviridae. The two most commonly known human polyomaviruses, BK virus and JC virus were first described in the 1970s. Newer human polyomaviruses, namely KI polyoma virus, WU polyoma virus and Merkel cell poly...

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Bibliographic Details
Published in:The Journal of infection 2014-01, Vol.68, p.S2-S8
Main Authors: Pinto, Michelle, Dobson, Simon
Format: Article
Language:English
Subjects:
BK Virus
BK Virus - genetics
BK Virus - isolation & purification
BK Virus - physiology
Humans
Immunocompromised Host
Infectious Disease
JC Virus
JC Virus - genetics
JC Virus - isolation & purification
JC Virus - physiology
Polyomavirus
Polyomavirus Infections - diagnosis
Polyomavirus Infections - epidemiology
Polyomavirus Infections - pathology
Polyomavirus Infections - virology
Virus Activation
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Summary:Summary Polyomaviruses are ubiquitous, species-specific viruses belonging to the family Papovaviridae. The two most commonly known human polyomaviruses, BK virus and JC virus were first described in the 1970s. Newer human polyomaviruses, namely KI polyoma virus, WU polyoma virus and Merkel cell polyoma virus were identified in the last five years. Most humans encounter BK and JC virus during childhood, causing mild illness. However, when reactivated or acquired in the immunocompromised host, BK and JC virus have been implicated in a number of human clinical disease states. BK is most commonly associated with renal involvement, such as ureteral stenosis, hemorrhagic cystitis and nephropathy. Less commonly, it is associated with pneumonitis, retinitis, liver disease and meningoencephalitis. JC virus is most well known for its association with progressive multifocal leukoencephalopathy, and is possibly implicated in the development of various human neoplasms. The following chapter will outline the basic virology, epidemiology and clinical manifestations of BK and JC virus and discuss relevant diagnostic and treatment options.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2013.09.009