In vitro antioxidant and antitumor activities of different sulfated polysaccharides isolated from three algae

•Ultrasonic extraction coupled with radial flow chromatography to separate sulfated polysaccharides from three algae.•Antioxidant and antitumor activities in vitro were studied and compared.•UFP with lower sulfate content exhibited excellent antioxidant activities but showed the least inhibitory eff...

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Bibliographic Details
Published in:International journal of biological macromolecules 2013-11, Vol.62 (1-2), p.155-161
Main Authors: Shao, Ping, Chen, Xiaoxiao, Sun, Peilong
Format: Article
Language:English
Subjects:
antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidant activity
antioxidants
Antitumor activity
Cell Line, Tumor
Cell Proliferation - drug effects
chromatography
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Free Radicals - chemistry
Gloiopeltis
Gloiopeltis furcata
Humans
neoplasm cells
polysaccharides
Polysaccharides - chemistry
Polysaccharides - pharmacology
Rhodophyta - chemistry
Sargassum
Sargassum - chemistry
stomach neoplasms
Sulfated polysaccharide
sulfates
Sulfates - chemistry
superoxide anion
ultrasonics
Ulva
Ulva - chemistry
Ulva fasciata
uronic acids
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Summary:•Ultrasonic extraction coupled with radial flow chromatography to separate sulfated polysaccharides from three algae.•Antioxidant and antitumor activities in vitro were studied and compared.•UFP with lower sulfate content exhibited excellent antioxidant activities but showed the least inhibitory effects for cancer cells.•The relationships between properties and bioactivities are preliminarily revealed. Three sulfated polysaccharides(Ulva fasciata (UFP), Gloiopeltis furcata (GFP), Sargassum henslouianum (SHP))were isolated from three algae including green alga Ulva fasciata, red alga Gloiopeltis furcata and brown alga Sargassum henslouianum by ultrasonic extraction and radial flow chromatography. Their in vitro antioxidant and antitumor activities were investigated and compared. Among these three polysaccharides, UFP, with relatively lower sulfate content, exhibited excellent antioxidant activities in superoxide radical assay, ABTS assay and DPPH assay; however, it demonstrated the minimal inhibitory effects on growth of MKN45 gastric cancer cells and DLD intestinal cancer cells. SHP with the lowest sulfate content gained relatively lower radical scavenging rates but showed significantly higher antitumor activities. These results indicated that the in vitro antitumor and antioxidant activities of the three polysaccharides may be related to combined effects of sulfate content and uronic acid content.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2013.08.023