Cancer Incidence of Workers Exposed to Dimethylformamide and/or Acrylonitrile

This study was to determine whether exposure to dimethylformamide (DMF) and acrylonitrile (ACN) separately or in combination, was associated with increased cancer incidence. Workers exposed to DMF and/or ACN were observed from 1956 through 1984 for cancer incidence. The workers exposed to DMF but no...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 1988-10, Vol.30 (10), p.813-818
Main Authors: Chen, Jean L., Fayerweather, William E., Pell, Sidney
Format: Article
Language:English
Subjects:
Acrylonitrile - adverse effects
Biological and medical sciences
Cohort Studies
Dimethylformamide - adverse effects
Humans
Male
Medical sciences
Neoplasms - chemically induced
Neoplasms - epidemiology
Nitriles - adverse effects
Occupational Diseases - chemically induced
Occupational Diseases - epidemiology
ORIGINAL ARTICLES
Otorhinolaryngology. Stomatology
Retrospective Studies
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Description
Summary:This study was to determine whether exposure to dimethylformamide (DMF) and acrylonitrile (ACN) separately or in combination, was associated with increased cancer incidence. Workers exposed to DMF and/or ACN were observed from 1956 through 1984 for cancer incidence. The workers exposed to DMF but not ACN showed significant excesses in incidence for buccal cavity and pharynx cancer and malignant melanoma. A significant excess of prostate cancer incidence was observed among workers exposed to DMF and ACN. No doseresponse relationships were observed between DMF or ACN exposure and cancer incidence. The significant excesses in cancer incidence among employees exposed to DMF and/or ACN could be due to statistical chance or other factors, such as tobacco and alcohol consumption. Further studies are warranted.
ISSN:0096-1736
1076-2752
2332-3795
DOI:10.1097/00043764-198810000-00013