Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors

Two distinct v-erbA-related cDNA clones representing the products of different genes were isolated from a rat liver cDNA library. The first, rc-erbA- alpha , was 82% identical to v-erbA and encoded a polypeptide with a calculated molecular mass of 45,000 daltons. This cDNA clone arises from the same...

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Bibliographic Details
Published in:The Journal of biological chemistry 1985-01, Vol.263 (25), p.12770-12777
Main Authors: Murray, M B, Zilz, N D, McCreary, N L, MacDonald, MJ, Towle, H C
Format: Article
Language:English
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Summary:Two distinct v-erbA-related cDNA clones representing the products of different genes were isolated from a rat liver cDNA library. The first, rc-erbA- alpha , was 82% identical to v-erbA and encoded a polypeptide with a calculated molecular mass of 45,000 daltons. This cDNA clone arises from the same gene product as a v-erbA-related cDNA isolated from rat brain by Thompson et al. The second cDNA clone, rc-erbA- beta , was 76% identical to v-erbA and encoded a polypeptide with a calculated molecular mass of 52,000 daltons.
ISSN:0021-9258