Comparison of responsiveness to the monocytosis-producing activity of Listeria monocytogenes in mice genetically susceptible or resistant to listeriosis

Injection of a monocytosis producing activity (MPA) from Listeria monocytogenes caused a dose-dependent elevation in numbers of macrophage colony forming units (CFU-m) in bone marrow and in peripheral blood. The increase could be seen as early as 8 h after injection of MPA and persisted until 72 h a...

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Bibliographic Details
Main Authors: Galsworthy, S B, Fewster, D
Format: Conference Proceeding
Language:English
Subjects:
Listeria monocytogenes
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Summary:Injection of a monocytosis producing activity (MPA) from Listeria monocytogenes caused a dose-dependent elevation in numbers of macrophage colony forming units (CFU-m) in bone marrow and in peripheral blood. The increase could be seen as early as 8 h after injection of MPA and persisted until 72 h after injection. Serum from MPA-treated animals, capable of inducing monocytosis, also caused an elevation in numbers of CFU-m. Since both B10.D2 old (C5-deficient) and B10.D2 new (C5-sufficient) mice, responded comparably to MPA, the unresponsiveness in A/J mice cannot be attributed solely to lack of C-5. The authors results are consistent with the idea that A/J mice lack or are unresponsive to the mPA-induced serum factor which promotes monocytosis.
ISSN:0300-8126