Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization

A novel Pd-catalyzed/Cu-mediated oxidative cyclization has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C-N and C-O bonds. In this protocol, four hydrogen atoms were removed and water was used as the oxygen atom source.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (27), p.3609-3611
Main Authors: Zheng, Jia, Zhang, Min, Huang, Liangbin, Hu, Xiaohan, Wu, Wanqing, Huang, Huawen, Jiang, Huangfeng
Format: Article
Language:English
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Summary:A novel Pd-catalyzed/Cu-mediated oxidative cyclization has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C-N and C-O bonds. In this protocol, four hydrogen atoms were removed and water was used as the oxygen atom source.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc49788g