Sodium fluoride mouthrinse used twice daily increased incipient caries lesion remineralization in an in situ model

• Published in: Journal of dentistry 2014-03, Vol.42 (3), p.271-278
• Main Authors: Songsiripradubboon, Siriporn, Hamba, Hidenori, Trairatvorakul, Chutima, Tagami, Junji
• Format: Article
• Language: English
• Subjects: Calcium Phosphates - administration & dosage; Cariostatic Agents - administration & dosage; Cross-Over Studies; Dental Caries - prevention & control; Dental Enamel - chemistry; Dental Enamel - drug effects; Dentistry; Fluoride; Fluorides - administration & dosage; Humans; Micro-CT; Minerals - analysis; Mouthrinse; Mouthwashes - administration & dosage; Orthodontic Brackets; Phosphates - administration & dosage; Proximal caries; Remineralization; Single-Blind Method; Sodium Fluoride - administration & dosage; Tooth Remineralization - methods; Toothpastes - administration & dosage; X-Ray Microtomography - methods; Young Adult
• ISSN: 0300-5712; 1879-176X
• DOI: 10.1016/j.jdent.2013.12.012

Abstract Objectives To investigate the remineralizing effects of fluoride mouthrinses used at different times and frequency in addition to fluoride toothpaste. Methods A randomized crossover single blinded study comprised 4 experimental phases of 21 days each. Twelve orthodontic volunteers were fixed with an orthodontic bracket containing an artificial carious enamel slab, which was from the same tooth in all 4 phases, and were randomly assigned to the following groups: (1) brushing with F toothpaste 2× per day (F- brush), (2) F- brush + rinsing with 0.05% NaF (F- rinse) after lunch, (3) F- brush + F-rinse before bedtime, and (4) F- brush + F- rinse 2× per day. Mean mineral gain after each phase was determined from mineral density profiles obtained using Micro-CT. Results The mean mineral gain in all treatments with F- brush and F-rinse were significantly greater than those in F- brush ( p < 0.05). Moreover F- rinse 2× per day increased lesion remineralization more than F- rinse once a day. Conclusions The twice-daily use of 0.05% NaF mouthrinse combined with twice-daily regular use of fluoride toothpaste resulted in the greatest remineralization of incipient caries. These data indicate that rinsing frequency is a factor affecting the effectiveness of fluoride mouthrinse. Clinical significance The rinsing frequency of NaF mouthrinse, when used with fluoride toothpaste, also affects the remineralization. This finding, if confirmed by a clinical study, would lead to a new recommendation for fluoride mouthrinse used in high caries risk patients who could benefit from using it twice a day.