Clinical effect of Maixuekang Capsule (脉血康胶囊) on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention

Objective To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (脉血康胶囊, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI). M...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2014-02, Vol.20 (2), p.88-93
Main Authors: Ge, Chang-jiang, Yuan, Fei, Feng, Li-xia, Lv, Shu-zheng, Liu, Hong, Song, Xian-tao, Chen, Xin, Huo, Yong
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - drug therapy
Acute Coronary Syndrome - surgery
Adenosine Diphosphate - pharmacology
Aged
C-Reactive Protein - metabolism
Capsules
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Female
Follow-Up Studies
Humans
Male
Medicine
Medicine & Public Health
Original Article
Percutaneous Coronary Intervention
Platelet Aggregation - drug effects
Prognosis
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Summary:Objective To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (脉血康胶囊, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI). Methods A total of 236 patients with acute coronary syndrome, who received successful PCI, were randomly assigned to a trial group (116 cases) and a control group (120 cases) according to random numbers; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent forms. In the trial group, the patients were treated with MKC combined with routine medication, and in the control group the patients were treated with routine medication. The therapeutic course for the two groups was 12 months and the follow-up was 12 months. The levels of ADP-induced platelet aggregation rate and serum high-sensitive C-reactive protein (hs-CRP) were determined before PCI, 12 h and 30 days after PCI. In the meantime, the incidence of cardio-/cerebrovascular events was recorded during the 12-month follow-up. Results Compared with before PCI, the levels of ADP-induced platelet aggregation rate and serum hs-CRP were significantly higher at 12 h after PCI ( P
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-013-1580-x