Loading…
Clinical effect of Maixuekang Capsule (脉血康胶囊) on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention
Objective To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (脉血康胶囊, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI). M...
Saved in:
| Published in: | Chinese journal of integrative medicine 2014-02, Vol.20 (2), p.88-93 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c344t-5658a45299edd1d6b70f093273d7038f5cf95200fdc65ce5f0bdc547f3eba21d3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c344t-5658a45299edd1d6b70f093273d7038f5cf95200fdc65ce5f0bdc547f3eba21d3 |
| container_end_page | 93 |
| container_issue | 2 |
| container_start_page | 88 |
| container_title | Chinese journal of integrative medicine |
| container_volume | 20 |
| creator | Ge, Chang-jiang Yuan, Fei Feng, Li-xia Lv, Shu-zheng Liu, Hong Song, Xian-tao Chen, Xin Huo, Yong |
| description | Objective
To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (脉血康胶囊, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI).
Methods
A total of 236 patients with acute coronary syndrome, who received successful PCI, were randomly assigned to a trial group (116 cases) and a control group (120 cases) according to random numbers; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent forms. In the trial group, the patients were treated with MKC combined with routine medication, and in the control group the patients were treated with routine medication. The therapeutic course for the two groups was 12 months and the follow-up was 12 months. The levels of ADP-induced platelet aggregation rate and serum high-sensitive C-reactive protein (hs-CRP) were determined before PCI, 12 h and 30 days after PCI. In the meantime, the incidence of cardio-/cerebrovascular events was recorded during the 12-month follow-up.
Results
Compared with before PCI, the levels of ADP-induced platelet aggregation rate and serum hs-CRP were significantly higher at 12 h after PCI (
P |
| doi_str_mv | 10.1007/s11655-013-1580-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1507191050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1507191050</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-5658a45299edd1d6b70f093273d7038f5cf95200fdc65ce5f0bdc547f3eba21d3</originalsourceid><addsrcrecordid>eNp9kbtuFTEQhi0EIiHwADTIZSg2jNfrvZToiJsUlAZqy8ceHxx27cXeDScdEjTwCjTwEkHK-0Q6j4GjDdBRzUj_RTP6CHnI4IgBNE8SY7UQBTBeMNFCsb1F9lnX8QIqKG_nvW7KvDOxR-6ldAogmhrEXbJXVpy3rK33yY9V77zTqqdoLeqJBktfK7ed8b3yG7pSY5p7pIe7L193Pz9dXf7afb64-v7tMQ2e9sFvignjQMcYNj4kl6jzdFSTQz8l-tFN76jS84RUhxi8iuc0nXsTw4BU2ZykI8asK49hTv9MzmftLHe44O-TO1b1CR_czAPy9vmzN6uXxfHJi1erp8eF5lU1FaIWrapE2XVoDDP1ugELHS8bbhrgrRXadqIEsEbXQqOwsDZaVI3luFYlM_yAHC69-ZcPM6ZJDi5p7PvlOMkENKxjICBb2WLVMaQU0coxuiEfLhnIazByASMzGHkNRm5z5tFN_bwe0PxN_CGRDeViSFnyG4zyNMzR55f_0_obdo-iaA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507191050</pqid></control><display><type>article</type><title>Clinical effect of Maixuekang Capsule (脉血康胶囊) on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention</title><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Ge, Chang-jiang ; Yuan, Fei ; Feng, Li-xia ; Lv, Shu-zheng ; Liu, Hong ; Song, Xian-tao ; Chen, Xin ; Huo, Yong</creator><creatorcontrib>Ge, Chang-jiang ; Yuan, Fei ; Feng, Li-xia ; Lv, Shu-zheng ; Liu, Hong ; Song, Xian-tao ; Chen, Xin ; Huo, Yong</creatorcontrib><description>Objective
To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (脉血康胶囊, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI).
Methods
A total of 236 patients with acute coronary syndrome, who received successful PCI, were randomly assigned to a trial group (116 cases) and a control group (120 cases) according to random numbers; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent forms. In the trial group, the patients were treated with MKC combined with routine medication, and in the control group the patients were treated with routine medication. The therapeutic course for the two groups was 12 months and the follow-up was 12 months. The levels of ADP-induced platelet aggregation rate and serum high-sensitive C-reactive protein (hs-CRP) were determined before PCI, 12 h and 30 days after PCI. In the meantime, the incidence of cardio-/cerebrovascular events was recorded during the 12-month follow-up.
Results
Compared with before PCI, the levels of ADP-induced platelet aggregation rate and serum hs-CRP were significantly higher at 12 h after PCI (
P
<0.05). They were significantly reduced after 30-day-treatment of MKC, showing statistical differences when compared with those in the control group (
P
<0.05). During the 12-month follow-up, the incidence of cardio-/cerebrovascular events was significantly lower in the trial group than in the control group (6.9% vs. 12.5%,
P
<0.01).
Conclusions
ADP-induced platelet aggregation function was significantly elevated after PCI. MKC improved the prognosis of patients with acute coronary syndrome, possibly through inhibiting the platelet aggregation, fighting against inflammation, and protecting the vascular endothelial function.</description><identifier>ISSN: 1672-0415</identifier><identifier>EISSN: 1993-0402</identifier><identifier>DOI: 10.1007/s11655-013-1580-x</identifier><identifier>PMID: 24338186</identifier><language>eng</language><publisher>Heidelberg: Chinese Association of Traditional and Western Medicine</publisher><subject>Acute Coronary Syndrome - drug therapy ; Acute Coronary Syndrome - surgery ; Adenosine Diphosphate - pharmacology ; Aged ; C-Reactive Protein - metabolism ; Capsules ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Female ; Follow-Up Studies ; Humans ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Percutaneous Coronary Intervention ; Platelet Aggregation - drug effects ; Prognosis</subject><ispartof>Chinese journal of integrative medicine, 2014-02, Vol.20 (2), p.88-93</ispartof><rights>Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-5658a45299edd1d6b70f093273d7038f5cf95200fdc65ce5f0bdc547f3eba21d3</citedby><cites>FETCH-LOGICAL-c344t-5658a45299edd1d6b70f093273d7038f5cf95200fdc65ce5f0bdc547f3eba21d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24338186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ge, Chang-jiang</creatorcontrib><creatorcontrib>Yuan, Fei</creatorcontrib><creatorcontrib>Feng, Li-xia</creatorcontrib><creatorcontrib>Lv, Shu-zheng</creatorcontrib><creatorcontrib>Liu, Hong</creatorcontrib><creatorcontrib>Song, Xian-tao</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Huo, Yong</creatorcontrib><title>Clinical effect of Maixuekang Capsule (脉血康胶囊) on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention</title><title>Chinese journal of integrative medicine</title><addtitle>Chin. J. Integr. Med</addtitle><addtitle>Chin J Integr Med</addtitle><description>Objective
To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (脉血康胶囊, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI).
Methods
A total of 236 patients with acute coronary syndrome, who received successful PCI, were randomly assigned to a trial group (116 cases) and a control group (120 cases) according to random numbers; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent forms. In the trial group, the patients were treated with MKC combined with routine medication, and in the control group the patients were treated with routine medication. The therapeutic course for the two groups was 12 months and the follow-up was 12 months. The levels of ADP-induced platelet aggregation rate and serum high-sensitive C-reactive protein (hs-CRP) were determined before PCI, 12 h and 30 days after PCI. In the meantime, the incidence of cardio-/cerebrovascular events was recorded during the 12-month follow-up.
Results
Compared with before PCI, the levels of ADP-induced platelet aggregation rate and serum hs-CRP were significantly higher at 12 h after PCI (
P
<0.05). They were significantly reduced after 30-day-treatment of MKC, showing statistical differences when compared with those in the control group (
P
<0.05). During the 12-month follow-up, the incidence of cardio-/cerebrovascular events was significantly lower in the trial group than in the control group (6.9% vs. 12.5%,
P
<0.01).
Conclusions
ADP-induced platelet aggregation function was significantly elevated after PCI. MKC improved the prognosis of patients with acute coronary syndrome, possibly through inhibiting the platelet aggregation, fighting against inflammation, and protecting the vascular endothelial function.</description><subject>Acute Coronary Syndrome - drug therapy</subject><subject>Acute Coronary Syndrome - surgery</subject><subject>Adenosine Diphosphate - pharmacology</subject><subject>Aged</subject><subject>C-Reactive Protein - metabolism</subject><subject>Capsules</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Percutaneous Coronary Intervention</subject><subject>Platelet Aggregation - drug effects</subject><subject>Prognosis</subject><issn>1672-0415</issn><issn>1993-0402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kbtuFTEQhi0EIiHwADTIZSg2jNfrvZToiJsUlAZqy8ceHxx27cXeDScdEjTwCjTwEkHK-0Q6j4GjDdBRzUj_RTP6CHnI4IgBNE8SY7UQBTBeMNFCsb1F9lnX8QIqKG_nvW7KvDOxR-6ldAogmhrEXbJXVpy3rK33yY9V77zTqqdoLeqJBktfK7ed8b3yG7pSY5p7pIe7L193Pz9dXf7afb64-v7tMQ2e9sFvignjQMcYNj4kl6jzdFSTQz8l-tFN76jS84RUhxi8iuc0nXsTw4BU2ZykI8asK49hTv9MzmftLHe44O-TO1b1CR_czAPy9vmzN6uXxfHJi1erp8eF5lU1FaIWrapE2XVoDDP1ugELHS8bbhrgrRXadqIEsEbXQqOwsDZaVI3luFYlM_yAHC69-ZcPM6ZJDi5p7PvlOMkENKxjICBb2WLVMaQU0coxuiEfLhnIazByASMzGHkNRm5z5tFN_bwe0PxN_CGRDeViSFnyG4zyNMzR55f_0_obdo-iaA</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Ge, Chang-jiang</creator><creator>Yuan, Fei</creator><creator>Feng, Li-xia</creator><creator>Lv, Shu-zheng</creator><creator>Liu, Hong</creator><creator>Song, Xian-tao</creator><creator>Chen, Xin</creator><creator>Huo, Yong</creator><general>Chinese Association of Traditional and Western Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Clinical effect of Maixuekang Capsule (脉血康胶囊) on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention</title><author>Ge, Chang-jiang ; Yuan, Fei ; Feng, Li-xia ; Lv, Shu-zheng ; Liu, Hong ; Song, Xian-tao ; Chen, Xin ; Huo, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-5658a45299edd1d6b70f093273d7038f5cf95200fdc65ce5f0bdc547f3eba21d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Coronary Syndrome - drug therapy</topic><topic>Acute Coronary Syndrome - surgery</topic><topic>Adenosine Diphosphate - pharmacology</topic><topic>Aged</topic><topic>C-Reactive Protein - metabolism</topic><topic>Capsules</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Percutaneous Coronary Intervention</topic><topic>Platelet Aggregation - drug effects</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ge, Chang-jiang</creatorcontrib><creatorcontrib>Yuan, Fei</creatorcontrib><creatorcontrib>Feng, Li-xia</creatorcontrib><creatorcontrib>Lv, Shu-zheng</creatorcontrib><creatorcontrib>Liu, Hong</creatorcontrib><creatorcontrib>Song, Xian-tao</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Huo, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chinese journal of integrative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ge, Chang-jiang</au><au>Yuan, Fei</au><au>Feng, Li-xia</au><au>Lv, Shu-zheng</au><au>Liu, Hong</au><au>Song, Xian-tao</au><au>Chen, Xin</au><au>Huo, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical effect of Maixuekang Capsule (脉血康胶囊) on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention</atitle><jtitle>Chinese journal of integrative medicine</jtitle><stitle>Chin. J. Integr. Med</stitle><addtitle>Chin J Integr Med</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>20</volume><issue>2</issue><spage>88</spage><epage>93</epage><pages>88-93</pages><issn>1672-0415</issn><eissn>1993-0402</eissn><abstract>Objective
To study the changes of adenosine diphosphate (ADP)-induced platelet aggregation rate, and evaluate the effects of Maixuekang Capsule (脉血康胶囊, MKC) on platelet aggregation rate and long-term prognosis of patients with acute coronary syndrome after percutaneous coronary intervention (PCI).
Methods
A total of 236 patients with acute coronary syndrome, who received successful PCI, were randomly assigned to a trial group (116 cases) and a control group (120 cases) according to random numbers; treatment allocation occurred when the participants met the inclusion criteria and signed the informed consent forms. In the trial group, the patients were treated with MKC combined with routine medication, and in the control group the patients were treated with routine medication. The therapeutic course for the two groups was 12 months and the follow-up was 12 months. The levels of ADP-induced platelet aggregation rate and serum high-sensitive C-reactive protein (hs-CRP) were determined before PCI, 12 h and 30 days after PCI. In the meantime, the incidence of cardio-/cerebrovascular events was recorded during the 12-month follow-up.
Results
Compared with before PCI, the levels of ADP-induced platelet aggregation rate and serum hs-CRP were significantly higher at 12 h after PCI (
P
<0.05). They were significantly reduced after 30-day-treatment of MKC, showing statistical differences when compared with those in the control group (
P
<0.05). During the 12-month follow-up, the incidence of cardio-/cerebrovascular events was significantly lower in the trial group than in the control group (6.9% vs. 12.5%,
P
<0.01).
Conclusions
ADP-induced platelet aggregation function was significantly elevated after PCI. MKC improved the prognosis of patients with acute coronary syndrome, possibly through inhibiting the platelet aggregation, fighting against inflammation, and protecting the vascular endothelial function.</abstract><cop>Heidelberg</cop><pub>Chinese Association of Traditional and Western Medicine</pub><pmid>24338186</pmid><doi>10.1007/s11655-013-1580-x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-0415 |
| ispartof | Chinese journal of integrative medicine, 2014-02, Vol.20 (2), p.88-93 |
| issn | 1672-0415 1993-0402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1507191050 |
| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Acute Coronary Syndrome - drug therapy Acute Coronary Syndrome - surgery Adenosine Diphosphate - pharmacology Aged C-Reactive Protein - metabolism Capsules Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Female Follow-Up Studies Humans Male Medicine Medicine & Public Health Original Article Percutaneous Coronary Intervention Platelet Aggregation - drug effects Prognosis |
| title | Clinical effect of Maixuekang Capsule (脉血康胶囊) on long-term prognosis in patients with acute coronary syndrome after percutaneous coronary intervention |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T10%3A13%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20effect%20of%20Maixuekang%20Capsule%20(%E8%84%89%E8%A1%80%E5%BA%B7%E8%83%B6%E5%9B%8A)%20on%20long-term%20prognosis%20in%20patients%20with%20acute%20coronary%20syndrome%20after%20percutaneous%20coronary%20intervention&rft.jtitle=Chinese%20journal%20of%20integrative%20medicine&rft.au=Ge,%20Chang-jiang&rft.date=2014-02-01&rft.volume=20&rft.issue=2&rft.spage=88&rft.epage=93&rft.pages=88-93&rft.issn=1672-0415&rft.eissn=1993-0402&rft_id=info:doi/10.1007/s11655-013-1580-x&rft_dat=%3Cproquest_cross%3E1507191050%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c344t-5658a45299edd1d6b70f093273d7038f5cf95200fdc65ce5f0bdc547f3eba21d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1507191050&rft_id=info:pmid/24338186&rfr_iscdi=true |