Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model

Dietary fish oil modifies skeletal muscle membrane fatty acid composition and oxygen efficiency similar to changes in the myocardium. Oxygen efficiency is a key determinant of sustained force in mammalian skeletal muscle. Therefore, in the present study, we tested the effects of a fish-oil diet on s...

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Bibliographic Details
Published in:British journal of nutrition 2014-03, Vol.111 (6), p.996-1003
Main Authors: PEOPLES, Gregory E, MCLENNAN, Peter L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - analysis
Diet
Dietary Fats, Unsaturated - administration & dosage
Docosahexaenoic Acids - administration & dosage
Docosahexaenoic Acids - pharmacology
Fatigue
Fatty acids
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-6 - administration & dosage
Feeding. Feeding behavior
Fish oils
Fish Oils - chemistry
Fundamental and applied biological sciences. Psychology
Glycogen - analysis
Hindlimb
Lactic Acid - blood
Male
Muscle Fatigue - drug effects
Muscle, Skeletal - chemistry
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Musculoskeletal system
Oxygen
Oxygen Consumption - drug effects
Rats
Rats, Wistar
Rodents
Striated muscle. Tendons
Tension
Ventilation
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: osteoarticular system, musculoskeletal system
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Summary:Dietary fish oil modifies skeletal muscle membrane fatty acid composition and oxygen efficiency similar to changes in the myocardium. Oxygen efficiency is a key determinant of sustained force in mammalian skeletal muscle. Therefore, in the present study, we tested the effects of a fish-oil diet on skeletal muscle fatigue under the stress of contraction using the rat in vivo autologous perfused hindlimb model. For 8 weeks, male Wistar rats were fed a diet rich in saturated fat (SF), a diet rich in n-6 PUFA or a diet rich in long-chain (LC) n-3 PUFA DHA derived from fish oil. In anaesthetised, mechanically ventilated rats, with their hindlimbs perfused with arterial blood at a constant flow, the gastrocnemius-plantaris-soleus muscle bundle was stimulated via sciatic nerve (2 Hz, 6-12 V, 0·05 ms) to contract repetitively for 30 min. Rats fed the n-3 PUFA diet developed higher maximum twitch tension than those fed the SF and n-6 PUFA diets (P
ISSN:0007-1145
1475-2662
DOI:10.1017/s0007114513003449