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Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation
Background Remote ischaemic pre‐conditioning attenuates myocardial injury. Because sulphonylurea drugs interfere with ischaemic and anaesthetic pre‐conditioning, we assessed whether remote ischaemic pre‐conditioning effects are altered in sulphonylurea‐treated diabetics. Methods Using the database o...
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| Published in: | Acta anaesthesiologica Scandinavica 2014-04, Vol.58 (4), p.453-462 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 462 |
| container_issue | 4 |
| container_start_page | 453 |
| container_title | Acta anaesthesiologica Scandinavica |
| container_volume | 58 |
| creator | KOTTENBERG, E. THIELMANN, M. KLEINBONGARD, P. FREY, U. H. HEINE, T. JAKOB, H. HEUSCH, G. PETERS, J. |
| description | Background
Remote ischaemic pre‐conditioning attenuates myocardial injury. Because sulphonylurea drugs interfere with ischaemic and anaesthetic pre‐conditioning, we assessed whether remote ischaemic pre‐conditioning effects are altered in sulphonylurea‐treated diabetics.
Methods
Using the database of our ongoing randomised, placebo‐controlled study (ClinicalTrials.gov NCT01406678), we assessed the troponin I concentration area under curve (measurements: baseline, 1, 6, 12, 24, 48, and 72 h post‐operatively) in sulphonylurea‐treated diabetics (n = 27) and non‐diabetics (n = 230) without and with remote ischaemic pre‐conditioning (three 5‐min periods of left upper arm ischaemia with 5‐min reperfusion each) during isoflurane anaesthesia before two‐ to three‐vessel coronary artery surgery.
Results
Remote ischaemic pre‐conditioning in non‐diabetic patients evoked a 41% decrease in the troponin I concentration area under curve (514 ng/ml × 72 h ± 600 vs. 302 ± 190, P = 0.001) but no change (404 ng/ml × 72 h ± 224 vs. 471 ± 383, P = 0.62) in sulphonylurea‐treated diabetics. There was no significant correlation between the troponin I concentration area under curve and arterial glucose concentrations, and the latter was not an independent confounder.
Conclusion
Cardioprotection by remote ischaemic pre‐conditioning during isoflurane anaesthesia is abolished in sulphonylurea‐treated diabetics. |
| doi_str_mv | 10.1111/aas.12278 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1507191439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1507191439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3928-50990923d21475e0cc9884f19992c5f2532f3333dbcdf1fcb14a8a70da4ef7153</originalsourceid><addsrcrecordid>eNpdkctu1DAUhi0EotPCghdAkdiwSevrOF6OBhguw0UqiKXl2E7HJbEHO6HMW_DInHRKF5yF7aP_-499fBB6RvA5gbgwppwTSmXzAC0IU6peCrl8iBYYY1ILIukJOi3lGlLGlXqMTigXvGGsWaA_Hw_JmuyC6at9TqO3Y0ixag9V9gOkVSh2Z_wQLMi-tim6MBMhXoFUmTb1oey8q0KsytTvdyke-il7U4-wjCBA6daPwZZqis7nqzRbbcopmjzf8ssUO_Umh2Lmwk_Qo870xT-928_Qtzevv67f1tvPm3fr1ba2TNGmFlgprChzlHApPLZWNQ3viFKKWtFRwWjHIFxrXUc62xJuGiOxM9x3kgh2hl4e60LXPydfRj1Aq77vTfRpKpoILIkinClAX_yHXqcpR3jdTC2p5A2RQD2_o6Z28E7vcxigQ_3vrwG4OAI3ofeHe51gPQ9RwxD17RD1anV5ewBHfXSEMvrf9w6Tf-ilZFLo7582Wnx59f7DervRl-wviRGg4w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506274817</pqid></control><display><type>article</type><title>Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>KOTTENBERG, E. ; THIELMANN, M. ; KLEINBONGARD, P. ; FREY, U. H. ; HEINE, T. ; JAKOB, H. ; HEUSCH, G. ; PETERS, J.</creator><creatorcontrib>KOTTENBERG, E. ; THIELMANN, M. ; KLEINBONGARD, P. ; FREY, U. H. ; HEINE, T. ; JAKOB, H. ; HEUSCH, G. ; PETERS, J.</creatorcontrib><description>Background
Remote ischaemic pre‐conditioning attenuates myocardial injury. Because sulphonylurea drugs interfere with ischaemic and anaesthetic pre‐conditioning, we assessed whether remote ischaemic pre‐conditioning effects are altered in sulphonylurea‐treated diabetics.
Methods
Using the database of our ongoing randomised, placebo‐controlled study (ClinicalTrials.gov NCT01406678), we assessed the troponin I concentration area under curve (measurements: baseline, 1, 6, 12, 24, 48, and 72 h post‐operatively) in sulphonylurea‐treated diabetics (n = 27) and non‐diabetics (n = 230) without and with remote ischaemic pre‐conditioning (three 5‐min periods of left upper arm ischaemia with 5‐min reperfusion each) during isoflurane anaesthesia before two‐ to three‐vessel coronary artery surgery.
Results
Remote ischaemic pre‐conditioning in non‐diabetic patients evoked a 41% decrease in the troponin I concentration area under curve (514 ng/ml × 72 h ± 600 vs. 302 ± 190, P = 0.001) but no change (404 ng/ml × 72 h ± 224 vs. 471 ± 383, P = 0.62) in sulphonylurea‐treated diabetics. There was no significant correlation between the troponin I concentration area under curve and arterial glucose concentrations, and the latter was not an independent confounder.
Conclusion
Cardioprotection by remote ischaemic pre‐conditioning during isoflurane anaesthesia is abolished in sulphonylurea‐treated diabetics.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1111/aas.12278</identifier><identifier>PMID: 24548338</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aged ; Anesthesia, General ; Area Under Curve ; Blood Glucose - metabolism ; Cohort Studies ; Constriction ; Diabetes Complications - therapy ; Female ; Humans ; Hypoglycemic Agents - adverse effects ; Hypoglycemic Agents - therapeutic use ; Ischemic Preconditioning, Myocardial - methods ; Male ; Mammary Arteries - transplantation ; Middle Aged ; Myocardial Reperfusion Injury - prevention & control ; Myocardial Revascularization - adverse effects ; Myocardial Revascularization - methods ; Retrospective Studies ; Saphenous Vein - transplantation ; Sternotomy ; Sulfonylurea Compounds - adverse effects ; Sulfonylurea Compounds - therapeutic use ; Troponin I - metabolism</subject><ispartof>Acta anaesthesiologica Scandinavica, 2014-04, Vol.58 (4), p.453-462</ispartof><rights>2014 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2014 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 The Acta Anaesthesiologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3928-50990923d21475e0cc9884f19992c5f2532f3333dbcdf1fcb14a8a70da4ef7153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24548338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOTTENBERG, E.</creatorcontrib><creatorcontrib>THIELMANN, M.</creatorcontrib><creatorcontrib>KLEINBONGARD, P.</creatorcontrib><creatorcontrib>FREY, U. H.</creatorcontrib><creatorcontrib>HEINE, T.</creatorcontrib><creatorcontrib>JAKOB, H.</creatorcontrib><creatorcontrib>HEUSCH, G.</creatorcontrib><creatorcontrib>PETERS, J.</creatorcontrib><title>Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Background
Remote ischaemic pre‐conditioning attenuates myocardial injury. Because sulphonylurea drugs interfere with ischaemic and anaesthetic pre‐conditioning, we assessed whether remote ischaemic pre‐conditioning effects are altered in sulphonylurea‐treated diabetics.
Methods
Using the database of our ongoing randomised, placebo‐controlled study (ClinicalTrials.gov NCT01406678), we assessed the troponin I concentration area under curve (measurements: baseline, 1, 6, 12, 24, 48, and 72 h post‐operatively) in sulphonylurea‐treated diabetics (n = 27) and non‐diabetics (n = 230) without and with remote ischaemic pre‐conditioning (three 5‐min periods of left upper arm ischaemia with 5‐min reperfusion each) during isoflurane anaesthesia before two‐ to three‐vessel coronary artery surgery.
Results
Remote ischaemic pre‐conditioning in non‐diabetic patients evoked a 41% decrease in the troponin I concentration area under curve (514 ng/ml × 72 h ± 600 vs. 302 ± 190, P = 0.001) but no change (404 ng/ml × 72 h ± 224 vs. 471 ± 383, P = 0.62) in sulphonylurea‐treated diabetics. There was no significant correlation between the troponin I concentration area under curve and arterial glucose concentrations, and the latter was not an independent confounder.
Conclusion
Cardioprotection by remote ischaemic pre‐conditioning during isoflurane anaesthesia is abolished in sulphonylurea‐treated diabetics.</description><subject>Aged</subject><subject>Anesthesia, General</subject><subject>Area Under Curve</subject><subject>Blood Glucose - metabolism</subject><subject>Cohort Studies</subject><subject>Constriction</subject><subject>Diabetes Complications - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Ischemic Preconditioning, Myocardial - methods</subject><subject>Male</subject><subject>Mammary Arteries - transplantation</subject><subject>Middle Aged</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Myocardial Revascularization - adverse effects</subject><subject>Myocardial Revascularization - methods</subject><subject>Retrospective Studies</subject><subject>Saphenous Vein - transplantation</subject><subject>Sternotomy</subject><subject>Sulfonylurea Compounds - adverse effects</subject><subject>Sulfonylurea Compounds - therapeutic use</subject><subject>Troponin I - metabolism</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpdkctu1DAUhi0EotPCghdAkdiwSevrOF6OBhguw0UqiKXl2E7HJbEHO6HMW_DInHRKF5yF7aP_-499fBB6RvA5gbgwppwTSmXzAC0IU6peCrl8iBYYY1ILIukJOi3lGlLGlXqMTigXvGGsWaA_Hw_JmuyC6at9TqO3Y0ixag9V9gOkVSh2Z_wQLMi-tim6MBMhXoFUmTb1oey8q0KsytTvdyke-il7U4-wjCBA6daPwZZqis7nqzRbbcopmjzf8ssUO_Umh2Lmwk_Qo870xT-928_Qtzevv67f1tvPm3fr1ba2TNGmFlgprChzlHApPLZWNQ3viFKKWtFRwWjHIFxrXUc62xJuGiOxM9x3kgh2hl4e60LXPydfRj1Aq77vTfRpKpoILIkinClAX_yHXqcpR3jdTC2p5A2RQD2_o6Z28E7vcxigQ_3vrwG4OAI3ofeHe51gPQ9RwxD17RD1anV5ewBHfXSEMvrf9w6Tf-ilZFLo7582Wnx59f7DervRl-wviRGg4w</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>KOTTENBERG, E.</creator><creator>THIELMANN, M.</creator><creator>KLEINBONGARD, P.</creator><creator>FREY, U. H.</creator><creator>HEINE, T.</creator><creator>JAKOB, H.</creator><creator>HEUSCH, G.</creator><creator>PETERS, J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation</title><author>KOTTENBERG, E. ; THIELMANN, M. ; KLEINBONGARD, P. ; FREY, U. H. ; HEINE, T. ; JAKOB, H. ; HEUSCH, G. ; PETERS, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3928-50990923d21475e0cc9884f19992c5f2532f3333dbcdf1fcb14a8a70da4ef7153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Anesthesia, General</topic><topic>Area Under Curve</topic><topic>Blood Glucose - metabolism</topic><topic>Cohort Studies</topic><topic>Constriction</topic><topic>Diabetes Complications - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Ischemic Preconditioning, Myocardial - methods</topic><topic>Male</topic><topic>Mammary Arteries - transplantation</topic><topic>Middle Aged</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Myocardial Revascularization - adverse effects</topic><topic>Myocardial Revascularization - methods</topic><topic>Retrospective Studies</topic><topic>Saphenous Vein - transplantation</topic><topic>Sternotomy</topic><topic>Sulfonylurea Compounds - adverse effects</topic><topic>Sulfonylurea Compounds - therapeutic use</topic><topic>Troponin I - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOTTENBERG, E.</creatorcontrib><creatorcontrib>THIELMANN, M.</creatorcontrib><creatorcontrib>KLEINBONGARD, P.</creatorcontrib><creatorcontrib>FREY, U. H.</creatorcontrib><creatorcontrib>HEINE, T.</creatorcontrib><creatorcontrib>JAKOB, H.</creatorcontrib><creatorcontrib>HEUSCH, G.</creatorcontrib><creatorcontrib>PETERS, J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOTTENBERG, E.</au><au>THIELMANN, M.</au><au>KLEINBONGARD, P.</au><au>FREY, U. H.</au><au>HEINE, T.</au><au>JAKOB, H.</au><au>HEUSCH, G.</au><au>PETERS, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2014-04</date><risdate>2014</risdate><volume>58</volume><issue>4</issue><spage>453</spage><epage>462</epage><pages>453-462</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract>Background
Remote ischaemic pre‐conditioning attenuates myocardial injury. Because sulphonylurea drugs interfere with ischaemic and anaesthetic pre‐conditioning, we assessed whether remote ischaemic pre‐conditioning effects are altered in sulphonylurea‐treated diabetics.
Methods
Using the database of our ongoing randomised, placebo‐controlled study (ClinicalTrials.gov NCT01406678), we assessed the troponin I concentration area under curve (measurements: baseline, 1, 6, 12, 24, 48, and 72 h post‐operatively) in sulphonylurea‐treated diabetics (n = 27) and non‐diabetics (n = 230) without and with remote ischaemic pre‐conditioning (three 5‐min periods of left upper arm ischaemia with 5‐min reperfusion each) during isoflurane anaesthesia before two‐ to three‐vessel coronary artery surgery.
Results
Remote ischaemic pre‐conditioning in non‐diabetic patients evoked a 41% decrease in the troponin I concentration area under curve (514 ng/ml × 72 h ± 600 vs. 302 ± 190, P = 0.001) but no change (404 ng/ml × 72 h ± 224 vs. 471 ± 383, P = 0.62) in sulphonylurea‐treated diabetics. There was no significant correlation between the troponin I concentration area under curve and arterial glucose concentrations, and the latter was not an independent confounder.
Conclusion
Cardioprotection by remote ischaemic pre‐conditioning during isoflurane anaesthesia is abolished in sulphonylurea‐treated diabetics.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24548338</pmid><doi>10.1111/aas.12278</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Acta anaesthesiologica Scandinavica, 2014-04, Vol.58 (4), p.453-462 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Aged Anesthesia, General Area Under Curve Blood Glucose - metabolism Cohort Studies Constriction Diabetes Complications - therapy Female Humans Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Ischemic Preconditioning, Myocardial - methods Male Mammary Arteries - transplantation Middle Aged Myocardial Reperfusion Injury - prevention & control Myocardial Revascularization - adverse effects Myocardial Revascularization - methods Retrospective Studies Saphenous Vein - transplantation Sternotomy Sulfonylurea Compounds - adverse effects Sulfonylurea Compounds - therapeutic use Troponin I - metabolism |
| title | Myocardial protection by remote ischaemic pre-conditioning is abolished in sulphonylurea-treated diabetics undergoing coronary revascularisation |
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