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Does gradual detorsion protect the ovary against ischemia–reperfusion injury in rats?
Aim Adnexal torsion is an infrequent and serious gynecologic surgical emergency. Adnexal torsion may result from pre-existing tubal or ovarian pathology or hyperstimulation of the ovary during ovulation. Early diagnosis and emergency surgical treatment (detorsion) are important to preserve fertility...
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| Published in: | Pediatric surgery international 2014-04, Vol.30 (4), p.437-440 |
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| container_issue | 4 |
| container_start_page | 437 |
| container_title | Pediatric surgery international |
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| creator | Ozkisacik, Sezen Yazici, Mesut Gursoy, Harun Culhaci, Nil |
| description | Aim
Adnexal torsion is an infrequent and serious gynecologic surgical emergency. Adnexal torsion may result from pre-existing tubal or ovarian pathology or hyperstimulation of the ovary during ovulation. Early diagnosis and emergency surgical treatment (detorsion) are important to preserve fertility and to prevent peritonitis or loss of the adnexa. However, during reperfusion, tissue damage is more severe than during ischemia because of oxygen-derived radicals. The present study aimed to investigate the protective effect of gradual detorsion on adnexal torsion.
Materials and methods
Twenty-one adult female rats were divided into three groups as sham-operated (Sh group,
n
= 7); torsion + detorsion (TD group,
n
= 7); and torsion + gradual detorsion (TGD group,
n
= 7). A midline laparotomy was performed under anesthesia. In the TD and TGD groups, the left adnexa along with tubal and ovarian vessels were twisted three times in a clockwise direction and fixed to the abdominal wall. After 30 h, detorsion was performed on the mesenteries of both TD and TGD groups. In the TGD group, however, detorsion was performed gradually: the ovarian mesentery was detorsioned 360°, followed by a 5-min pause, then a repeat of the cycle until full detorsion was achieved. Rats were killed 1 week later. Left ovaries were removed and evaluated histopathologically.
Results
The histopathological mean grade was significantly higher in the TD than in the TGD group (
p
|
| doi_str_mv | 10.1007/s00383-014-3480-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1507799578</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3245791071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-e5e2b1be31885eeecafafa2804d767f895a4abf025bf2baf98dc75433ae514653</originalsourceid><addsrcrecordid>eNp1kE9LwzAYxoMobk4_gBcpePFSTfomS3ISmX9B8KJ4DGn7duvo2pm0gje_g9_QT2K2ThFBcsghv-fJw4-QQ0ZPGaXyzFMKCmLKeAxc0Ri2yJBxkLFWDLbJkDKpYwpCDcie93NKqYKx3iWDhAumuYIheb5s0EdTZ_POVlGObeN82dTR0jUtZm3UzjBqXq17i-zUlrVvo9JnM1yU9vP9w-ESXdGtA2U97wJV1pGzrT_fJzuFrTwebO4Rebq-epzcxvcPN3eTi_s446DaGAUmKUsRmFICETNbhJMoynM5loXSwnKbFjQRaZGkttAqz6TgABYF42MBI3LS94bBLx361izCQKwqW2PTecMElVJrIVVAj_-g86ZzdVi3phjoBFaFrKcy13jvsDBLVy6CAMOoWVk3vXUTrJuVdQMhc7Rp7tIF5j-Jb80BSHrAh6d6iu7X1_-2fgGF1o7T</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507139235</pqid></control><display><type>article</type><title>Does gradual detorsion protect the ovary against ischemia–reperfusion injury in rats?</title><source>Springer Nature</source><creator>Ozkisacik, Sezen ; Yazici, Mesut ; Gursoy, Harun ; Culhaci, Nil</creator><creatorcontrib>Ozkisacik, Sezen ; Yazici, Mesut ; Gursoy, Harun ; Culhaci, Nil</creatorcontrib><description>Aim
Adnexal torsion is an infrequent and serious gynecologic surgical emergency. Adnexal torsion may result from pre-existing tubal or ovarian pathology or hyperstimulation of the ovary during ovulation. Early diagnosis and emergency surgical treatment (detorsion) are important to preserve fertility and to prevent peritonitis or loss of the adnexa. However, during reperfusion, tissue damage is more severe than during ischemia because of oxygen-derived radicals. The present study aimed to investigate the protective effect of gradual detorsion on adnexal torsion.
Materials and methods
Twenty-one adult female rats were divided into three groups as sham-operated (Sh group,
n
= 7); torsion + detorsion (TD group,
n
= 7); and torsion + gradual detorsion (TGD group,
n
= 7). A midline laparotomy was performed under anesthesia. In the TD and TGD groups, the left adnexa along with tubal and ovarian vessels were twisted three times in a clockwise direction and fixed to the abdominal wall. After 30 h, detorsion was performed on the mesenteries of both TD and TGD groups. In the TGD group, however, detorsion was performed gradually: the ovarian mesentery was detorsioned 360°, followed by a 5-min pause, then a repeat of the cycle until full detorsion was achieved. Rats were killed 1 week later. Left ovaries were removed and evaluated histopathologically.
Results
The histopathological mean grade was significantly higher in the TD than in the TGD group (
p
< 0.05).
Conclusion
Gradual detorsion can reduce reperfusion injury in a rat model of ovarian torsion. This method is easily applicable and may be a useful method for human patients with ovarian torsion.</description><identifier>ISSN: 0179-0358</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-014-3480-3</identifier><identifier>PMID: 24519483</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adnexal Diseases - complications ; Adnexal Diseases - therapy ; Animals ; Female ; Medicine ; Medicine & Public Health ; Original Article ; Ovary - blood supply ; Pediatric Surgery ; Pediatrics ; Rats ; Rats, Wistar ; Reperfusion Injury - etiology ; Reperfusion Injury - prevention & control ; Surgery ; Torsion Abnormality - complications ; Torsion Abnormality - therapy</subject><ispartof>Pediatric surgery international, 2014-04, Vol.30 (4), p.437-440</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-e5e2b1be31885eeecafafa2804d767f895a4abf025bf2baf98dc75433ae514653</citedby><cites>FETCH-LOGICAL-c438t-e5e2b1be31885eeecafafa2804d767f895a4abf025bf2baf98dc75433ae514653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24519483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozkisacik, Sezen</creatorcontrib><creatorcontrib>Yazici, Mesut</creatorcontrib><creatorcontrib>Gursoy, Harun</creatorcontrib><creatorcontrib>Culhaci, Nil</creatorcontrib><title>Does gradual detorsion protect the ovary against ischemia–reperfusion injury in rats?</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Aim
Adnexal torsion is an infrequent and serious gynecologic surgical emergency. Adnexal torsion may result from pre-existing tubal or ovarian pathology or hyperstimulation of the ovary during ovulation. Early diagnosis and emergency surgical treatment (detorsion) are important to preserve fertility and to prevent peritonitis or loss of the adnexa. However, during reperfusion, tissue damage is more severe than during ischemia because of oxygen-derived radicals. The present study aimed to investigate the protective effect of gradual detorsion on adnexal torsion.
Materials and methods
Twenty-one adult female rats were divided into three groups as sham-operated (Sh group,
n
= 7); torsion + detorsion (TD group,
n
= 7); and torsion + gradual detorsion (TGD group,
n
= 7). A midline laparotomy was performed under anesthesia. In the TD and TGD groups, the left adnexa along with tubal and ovarian vessels were twisted three times in a clockwise direction and fixed to the abdominal wall. After 30 h, detorsion was performed on the mesenteries of both TD and TGD groups. In the TGD group, however, detorsion was performed gradually: the ovarian mesentery was detorsioned 360°, followed by a 5-min pause, then a repeat of the cycle until full detorsion was achieved. Rats were killed 1 week later. Left ovaries were removed and evaluated histopathologically.
Results
The histopathological mean grade was significantly higher in the TD than in the TGD group (
p
< 0.05).
Conclusion
Gradual detorsion can reduce reperfusion injury in a rat model of ovarian torsion. This method is easily applicable and may be a useful method for human patients with ovarian torsion.</description><subject>Adnexal Diseases - complications</subject><subject>Adnexal Diseases - therapy</subject><subject>Animals</subject><subject>Female</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Ovary - blood supply</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion Injury - etiology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Surgery</subject><subject>Torsion Abnormality - complications</subject><subject>Torsion Abnormality - therapy</subject><issn>0179-0358</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kE9LwzAYxoMobk4_gBcpePFSTfomS3ISmX9B8KJ4DGn7duvo2pm0gje_g9_QT2K2ThFBcsghv-fJw4-QQ0ZPGaXyzFMKCmLKeAxc0Ri2yJBxkLFWDLbJkDKpYwpCDcie93NKqYKx3iWDhAumuYIheb5s0EdTZ_POVlGObeN82dTR0jUtZm3UzjBqXq17i-zUlrVvo9JnM1yU9vP9w-ESXdGtA2U97wJV1pGzrT_fJzuFrTwebO4Rebq-epzcxvcPN3eTi_s446DaGAUmKUsRmFICETNbhJMoynM5loXSwnKbFjQRaZGkttAqz6TgABYF42MBI3LS94bBLx361izCQKwqW2PTecMElVJrIVVAj_-g86ZzdVi3phjoBFaFrKcy13jvsDBLVy6CAMOoWVk3vXUTrJuVdQMhc7Rp7tIF5j-Jb80BSHrAh6d6iu7X1_-2fgGF1o7T</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Ozkisacik, Sezen</creator><creator>Yazici, Mesut</creator><creator>Gursoy, Harun</creator><creator>Culhaci, Nil</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Does gradual detorsion protect the ovary against ischemia–reperfusion injury in rats?</title><author>Ozkisacik, Sezen ; Yazici, Mesut ; Gursoy, Harun ; Culhaci, Nil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-e5e2b1be31885eeecafafa2804d767f895a4abf025bf2baf98dc75433ae514653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adnexal Diseases - complications</topic><topic>Adnexal Diseases - therapy</topic><topic>Animals</topic><topic>Female</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Ovary - blood supply</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion Injury - etiology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Surgery</topic><topic>Torsion Abnormality - complications</topic><topic>Torsion Abnormality - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozkisacik, Sezen</creatorcontrib><creatorcontrib>Yazici, Mesut</creatorcontrib><creatorcontrib>Gursoy, Harun</creatorcontrib><creatorcontrib>Culhaci, Nil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Family Health</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozkisacik, Sezen</au><au>Yazici, Mesut</au><au>Gursoy, Harun</au><au>Culhaci, Nil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does gradual detorsion protect the ovary against ischemia–reperfusion injury in rats?</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>30</volume><issue>4</issue><spage>437</spage><epage>440</epage><pages>437-440</pages><issn>0179-0358</issn><eissn>1437-9813</eissn><abstract>Aim
Adnexal torsion is an infrequent and serious gynecologic surgical emergency. Adnexal torsion may result from pre-existing tubal or ovarian pathology or hyperstimulation of the ovary during ovulation. Early diagnosis and emergency surgical treatment (detorsion) are important to preserve fertility and to prevent peritonitis or loss of the adnexa. However, during reperfusion, tissue damage is more severe than during ischemia because of oxygen-derived radicals. The present study aimed to investigate the protective effect of gradual detorsion on adnexal torsion.
Materials and methods
Twenty-one adult female rats were divided into three groups as sham-operated (Sh group,
n
= 7); torsion + detorsion (TD group,
n
= 7); and torsion + gradual detorsion (TGD group,
n
= 7). A midline laparotomy was performed under anesthesia. In the TD and TGD groups, the left adnexa along with tubal and ovarian vessels were twisted three times in a clockwise direction and fixed to the abdominal wall. After 30 h, detorsion was performed on the mesenteries of both TD and TGD groups. In the TGD group, however, detorsion was performed gradually: the ovarian mesentery was detorsioned 360°, followed by a 5-min pause, then a repeat of the cycle until full detorsion was achieved. Rats were killed 1 week later. Left ovaries were removed and evaluated histopathologically.
Results
The histopathological mean grade was significantly higher in the TD than in the TGD group (
p
< 0.05).
Conclusion
Gradual detorsion can reduce reperfusion injury in a rat model of ovarian torsion. This method is easily applicable and may be a useful method for human patients with ovarian torsion.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24519483</pmid><doi>10.1007/s00383-014-3480-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pediatric surgery international, 2014-04, Vol.30 (4), p.437-440 |
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| language | eng |
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| source | Springer Nature |
| subjects | Adnexal Diseases - complications Adnexal Diseases - therapy Animals Female Medicine Medicine & Public Health Original Article Ovary - blood supply Pediatric Surgery Pediatrics Rats Rats, Wistar Reperfusion Injury - etiology Reperfusion Injury - prevention & control Surgery Torsion Abnormality - complications Torsion Abnormality - therapy |
| title | Does gradual detorsion protect the ovary against ischemia–reperfusion injury in rats? |
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