Baker's yeast β-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk?

Strenuous aerobic exercise is known to weaken the immune system, and while many nutritional supplements have been proposed to boost post-exercise immunity, few are known to be effective. The purpose of the present study was to evaluate whether 10 d of supplementation with a defined source of baker&#...

Full description

Saved in:
Bibliographic Details
Published in:British journal of nutrition 2013-02, Vol.109 (3), p.478-486
Main Authors: Carpenter, K. C., Breslin, W. L., Davidson, T., Adams, A., McFarlin, B. K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
beta-Glucans - metabolism
Bicycling
Biological and medical sciences
Cells, Cultured
Cross-Over Studies
Cytokines - blood
Dietary Supplements
Double-Blind Method
Exercise
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunity, Innate
Immunomodulation
Leukocyte Count
Male
Monocytes - cytology
Monocytes - immunology
Monocytes - metabolism
Nutritional Immunology
Oryza sativa
Saccharomyces cerevisiae
Saccharomyces cerevisiae - metabolism
Stress, Physiological
Texas
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Strenuous aerobic exercise is known to weaken the immune system, and while many nutritional supplements have been proposed to boost post-exercise immunity, few are known to be effective. The purpose of the present study was to evaluate whether 10 d of supplementation with a defined source of baker's yeast β-glucan (BG, Wellmune WGP®) could minimise post-exercise immunosuppression. Recreationally active men and women (n 60) completed two 10 d trial conditions using a cross-over design with a 7 d washout period: placebo (rice flour) and baker's yeast BG (250 mg/d of β-1,3/1,6-glucans derived from Saccharomyces cerevisiae) before a bout of cycling (49 ± 6 min) in a hot (38 ± 2°C), humid (45 ± 2 % relative humidity) environment. Blood was collected at baseline (before supplement), pre- (PRE), post- (POST) and 2 h (2H) post-exercise. Total and subset monocyte concentration was measured by four-colour flow cytometry. Plasma cytokine levels and lipopolysaccharide (LPS)-stimulated cytokine production were measured using separate multiplex assays. Total (CD14+) and pro-inflammatory monocyte concentrations (CD14+/CD16+) were significantly greater at POST and 2H (P
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114512001407