The association of CXCR4 expression with prognosis and clinicopathological indicators in colorectal carcinoma patients: a meta-analysis

Aims The clinical relevance of expression of chemokine receptor 4 (CXCR4) in colorectal carcinoma (CRC) remains controversial; our aim was to identify the precise relationship of CXCR4 to prognosis and clinicopathological features. Methods and results A meta‐analysis was performed. Original data inc...

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Bibliographic Details
Published in:Histopathology 2014-04, Vol.64 (5), p.701-712
Main Authors: Lv, Shunzeng, Yang, Yakun, Kwon, Sera, Han, Mingzhi, Zhao, Fangfang, Kang, Huihui, Dai, Congxin, Wang, Renzhi
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
clinicopathological features
colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
CXCR4
Disease-Free Survival
Female
Gene Expression
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphatic Metastasis
Male
meta-analysis
Prognosis
Receptors, CXCR4 - genetics
Receptors, CXCR4 - metabolism
Reverse Transcriptase Polymerase Chain Reaction
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Summary:Aims The clinical relevance of expression of chemokine receptor 4 (CXCR4) in colorectal carcinoma (CRC) remains controversial; our aim was to identify the precise relationship of CXCR4 to prognosis and clinicopathological features. Methods and results A meta‐analysis was performed. Original data included the hazard ratios (HRs) of recurrence‐free survival (RFS), overall survival (OS) and odds ratio (OR) in CRC patients. We pooled HR/OR with 95% confidence intervals (CIs) to estimate the hazard. A total of 20 published studies (including 2253 patients) were eligible. RFS and OS were related significantly to CXCR4 expression, with HRs 1.62 (95% CI 1.24–2.11; P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12321