Healing efficacy of sea buckthorn ( Hippophae rhamnoides L.) seed oil in an ovine burn wound model

Abstract To investigate the efficacy of sea buckthorn (SBT) seed oil – a rich source of substances known to have anti-atherogenic and cardioprotective activity, and to promote skin and mucosa epithelization – on burn wound healing, five adult sheep were subjected to 3rd degree flame burns. Two burn...

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Bibliographic Details
Published in:Burns 2014-05, Vol.40 (3), p.511-519
Main Authors: Ito, Hiroshi, Asmussen, Sven, Traber, Daniel L, Cox, Robert A, Hawkins, Hal K, Connelly, Rhykka, Traber, Lillian D, Walker, Timothy W, Malgerud, Erik, Sakurai, Hiroyuki, Enkhbaatar, Perenlei
Format: Article
Language:English
Subjects:
Animals
Burn wounds
Burns - diagnostic imaging
Burns - surgery
Critical Care
Debridement
Disease Models, Animal
Hippophae
Laser-Doppler Flowmetry
Phytotherapy
Plant Oils - pharmacology
Sea buckthorn seed oil
Seeds
Sheep, Domestic
Skin autograft
Skin Transplantation - methods
Transplantation, Autologous
Ultrasonography
Wound Healing - drug effects
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Summary:Abstract To investigate the efficacy of sea buckthorn (SBT) seed oil – a rich source of substances known to have anti-atherogenic and cardioprotective activity, and to promote skin and mucosa epithelization – on burn wound healing, five adult sheep were subjected to 3rd degree flame burns. Two burn sites were made on the dorsum of the sheep and the eschar was excised down to the fascia. Split-thickness skin grafts were harvested, meshed, and fitted to the wounds. The autograft was placed on the fascia and SBT seed oil was topically applied to one recipient and one donor site, respectively, with the remaining sites treated with vehicle. The wound blood flow (LASER Doppler), and epithelization (ultrasound) were determined at 6, 14, and 21 days after injury. 14 days after grafting, the percentage of epithelization in the treated sites was greater (95 ± 2.2% vs. 83 ± 2.9%, p < 0.05) than in the untreated sites. Complete epithelization time was shorter in both treated recipient and donor sites (14.20 ± 0.48 vs. 19.60 ± 0.40 days, p < 0.05 and 13.40 ± 1.02 vs. 19.60 ± 0.50 days, p < 0.05, respectively) than in the untreated sites, confirmed by ultrasound. In conclusion, SBT seed oil has significant wound healing activity in full-thickness burns and split-thickness harvested wounds.
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2013.08.011