Histopathological assessment of tumour regression, nodal stage and status of resection margins determines prognosis in patients with oral squamous cell carcinoma treated with neoadjuvant radiochemotherapy

Objectives In advanced oral squamous cell carcinoma (OSCC), tumour regression after neoadjuvant radiochemotherapy seems to be an important prognostic factor. In this study, we intended to compare regression grading according to two previously described regression models and to analyse the associatio...

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Bibliographic Details
Published in:Oral diseases 2014-04, Vol.20 (3), p.e81-e89
Main Authors: Wedemeyer, I, Kreppel, M, Scheer, M, Zöller, JE, Büttner, R, Drebber, U
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Carcinoma, Squamous Cell - therapy
Chemoradiotherapy
Chemotherapy
Dentistry
Female
histopathological assessment
Histopathology
Humans
Male
Middle Aged
Mortality
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Mouth Neoplasms - surgery
Mouth Neoplasms - therapy
neoadjuvant radiochemotherapy
Neoadjuvant Therapy
Neoplasm Grading
Neoplasm Staging
Oral cancer
oral squamous cell carcinoma
Prognosis
Radiation therapy
regression grading
Remission Induction
Retrospective Studies
Survival Rate
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Summary:Objectives In advanced oral squamous cell carcinoma (OSCC), tumour regression after neoadjuvant radiochemotherapy seems to be an important prognostic factor. In this study, we intended to compare regression grading according to two previously described regression models and to analyse the association of tumour regression and other tumour characteristics with patients' characteristics and overall survival. Methods The retrospective study included 63 treatment‐naive patients with primary OSCC of stages II‐IV, who were treated with a concomitant neoadjuvant radiochemotherapy followed by radical surgery. Assessment of histopathological features was performed, there under regression grading according to two previously described regression models. Results Both tumour regression models provided comparable results in terms of distribution of different regression grades. In univariate analysis regression gradings (P = 0.003 and P = 0.007), ypT‐stage, ypN‐stage and status of resection margins (P 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12137