Effects of hyperbaric oxygen therapy on the viability of irradiated soft head and neck tissues in mice

Objectives Hyperbaric oxygen therapy (HBOT) is used clinically in irradiation‐induced injury to healthy tissues, but the effectiveness and working mechanism remain unclear. This study examined the effects of HBOT on irradiated salivary glands and tongue in a mouse model. Materials and Methods Mice w...

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Bibliographic Details
Published in:Oral diseases 2014-04, Vol.20 (3), p.e111-e119
Main Authors: Spiegelberg, L, Braks, JAM, Djasim, UM, Farrell, E, van der Wal, KGH, Wolvius, EB
Format: Article
Language:English
Subjects:
Animals
Dentistry
Disease Models, Animal
Female
Head & neck cancer
hyperbaric oxygen therapy
Hyperbaric Oxygenation
Mice
Mice, Inbred C3H
Oxygen therapy
Radiation Injuries - therapy
Radiation therapy
radiotherapy
regeneration
Rodents
salivary glands
Salivary Glands - radiation effects
tongue
Tongue - radiation effects
xerostomia
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Summary:Objectives Hyperbaric oxygen therapy (HBOT) is used clinically in irradiation‐induced injury to healthy tissues, but the effectiveness and working mechanism remain unclear. This study examined the effects of HBOT on irradiated salivary glands and tongue in a mouse model. Materials and Methods Mice were irradiated with a single dose (15 Gy) in the head and neck region and subjected to HBOT, either before or after irradiation. During the course of the treatments, salivary flow rates were measured and at different time points after radiation (2, 6, 10 and 24 weeks), salivary glands and tongue were harvested and (immuno) histochemically analysed. Results Proliferation and blood vessel density in salivary glands were enhanced by HBOT in the medium term (10 weeks after irradiation), while salivary flow rates were not influenced. In the long term, irradiation‐induced proliferation in the muscle tissue of the tongue was decreased by HBOT. Conclusion Hyperbaric oxygen therapy (HBOT) appears to stimulate regeneration or protection of salivary gland tissue following radiation therapy. Possible implications of the effect of HBOT on muscle tissue of the tongue for the prevention of dysphagia and trismus are discussed. This study provides insights on the cellular changes after HBOT and encourages further research on this topic to achieve a better implementation of the therapy in humans.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12162