Mechanical allodynia induced by traumatic brain injury is independent of restraint stress

•Periorbital and paw allodynia are induced by traumatic brain injury in rodents.•Periorbital sensory changes were greater on the side ipsilateral to the injury.•Mechanical allodynia is independent of restraint stress.•A stress response induced by head injury is species specific.•Rodent models of TBI...

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Bibliographic Details
Published in:Journal of neuroscience methods 2014-04, Vol.226, p.139-146
Main Authors: Macolino, Christine M., Daiutolo, Brittany V., Albertson, Brad K., Elliott, Melanie B.
Format: Article
Language:English
Subjects:
Animals
Brain Injuries - complications
Brain Injuries - physiopathology
Corticosterone
Corticosterone - blood
Disease Models, Animal
Face - physiopathology
Forelimb - physiopathology
Functional Laterality
Headache
Hindlimb - physiopathology
Hyperalgesia - etiology
Hyperalgesia - physiopathology
Male
Mechanical allodynia
Mice
Mice, Inbred C57BL
Pain Measurement
Pain Threshold
Post-Traumatic Headache - etiology
Post-Traumatic Headache - physiopathology
Rats
Rats, Sprague-Dawley
Restraint, Physical
Species
Stress
Stress, Psychological - complications
Stress, Psychological - physiopathology
Time Factors
Touch
Traumatic brain injury
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Summary:•Periorbital and paw allodynia are induced by traumatic brain injury in rodents.•Periorbital sensory changes were greater on the side ipsilateral to the injury.•Mechanical allodynia is independent of restraint stress.•A stress response induced by head injury is species specific.•Rodent models of TBI are useful to study headache and stress after head trauma. This study identifies the relationship between a test for post-traumatic headache and a marker for acute stress in rodent models of traumatic brain injury. C57BL/6 mice and Sprague Dawley rats were divided into Controlled Cortical Impact (CCI) injury, craniotomy (CR), and incision groups. Periorbital and paw allodynia were evaluated using the von Frey test prior to injury and up to four weeks post-operatively. Serum corticosterone was evaluated in groups with and without mild restraint. Periorbital and forepaw thresholds, but not hindpaw thresholds, were reduced in CCI and CR mice compared to incision (p
ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2014.01.008