Anticancer activity of Sargassum wightii Greville on Dalton's ascitic lymphoma

Sargassum wightii Greville is a marine brown alga belonging to the Sargassaceae family which has about 200 species. The ethanolic extract of the whole dry plant powder contained numerous phytoconstituents, including flavonoids. The study was focused on the anticancer activity of Sargassum wightii in...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2014-02, Vol.12 (2), p.114-120
Main Authors: Anjana, Ashwini, Ahamed, K.F.H Nazeer, Ravichandiran, V., Sumithra, M., Anbu, Jayaraman
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Ascites
Brown alga
Cancer
Cell Line, Tumor
Cell Proliferation
Dalton ascitic lymphoma
Flavonoids
Hematology
Humans
Lymphoma - drug therapy
Mice
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Sargassum
Sargassum wightii Greville
Survival Rate
Trypan blue assay
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Summary:Sargassum wightii Greville is a marine brown alga belonging to the Sargassaceae family which has about 200 species. The ethanolic extract of the whole dry plant powder contained numerous phytoconstituents, including flavonoids. The study was focused on the anticancer activity of Sargassum wightii in mice. The ethanolic extract of Sargassum wightii (EESW) at two dose levels was used to examine the anticancer activity in mice using DAL cell lines to induce cancer. The body weight, viable and non-viable tumor cell count, mean survival time, increase in life span, and hematological parameters were observed for anticancer activity of EESW. The intraperitoneal inoculation of DAL cells in mice significantly increased cancer cell count. The decrease in the cancer cell number observed in the EESW-treated group cancer animals indicates that the test drug has a significant inhibitory effect on the tumor cell proliferation. Treatment with EESW also showed a significant decrease in tumor weight, and hence increased the lifespan of DAL-treated mice. In addition, EESW administration significantly restored the hematological parameters in DAL-treated mice. The present study results suggest that administration of extract offers enhanced antioxidant potential. Therefore it can be concluded from this study that EESW possesses anticancer activity.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(14)60018-2