Relationship between parathyroid hormone and subclinical myocardial dysfunction in patients with severe psoriasis

Background Psoriasis is associated with an increased risk of cardiovascular disease although the mechanism remains unclear. Recent studies have shown that such patients have a high prevalence of vitamin D (vit‐D) deficiency and elevated parathyroid hormone (PTH) level. We hypothesized that vit‐D def...

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Published in:Journal of the European Academy of Dermatology and Venereology 2014-04, Vol.28 (4), p.461-468
Main Authors: Zhao, C.-T., Yeung, C.-K., Siu, C.-W., Tam, S., Chan, J., Chen, Y., Chan, H.-H., Tse, H.-F., Yiu, K.-H.
Format: Article
Language:English
Subjects:
Adult
Cardiomyopathies - blood
Cardiomyopathies - physiopathology
Female
Humans
Male
Middle Aged
Parathyroid Hormone - blood
Psoriasis - blood
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Summary:Background Psoriasis is associated with an increased risk of cardiovascular disease although the mechanism remains unclear. Recent studies have shown that such patients have a high prevalence of vitamin D (vit‐D) deficiency and elevated parathyroid hormone (PTH) level. We hypothesized that vit‐D deficiency and/or elevated PTH in psoriasis may contribute to left ventricular (LV) dysfunction. Methods Seventy‐four patients with severe psoriasis with no known cardiovascular disease and 53 age‐ and gender‐matched controls were recruited. All patients underwent detailed transthoracic echocardiography, including speckle tracking derived strains, and plasma levels of 25‐hydoxyvitamin D (25‐OHD), PTH and cardiac biomarkers including high sensitive C‐reactive protein (hs‐CRP), high sensitive troponin I (hs‐TNI) and brain natriuretic peptide (BNP) were measured. Results Despite similar systolic and diastolic LV function, patients with severe psoriasis had impaired LV global longitudinal (−18.1 ± 2.6 vs.−19.6 ± 2.9%, P 
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.12123