Diagnosis and classification of Kawasaki disease

Abstract Kawasaki disease is an acute systemic vasculitis of unknown etiology. Diagnosis is based on clinical criteria that include fever, exanthema, conjunctivitis, changes in the extremities, erythema of oral mucosa and lips and cervical lymphadenopathy. However, these criteria have low sensitivit...

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Bibliographic Details
Published in:Journal of autoimmunity 2014-02, Vol.48, p.113-117
Main Authors: Sánchez-Manubens, Judith, Bou, Rosa, Anton, Jordi
Format: Article
Language:English
Subjects:
Acute Disease
Allergy and Immunology
Asia - epidemiology
Autoantibodies - biosynthesis
Biological and medical sciences
Blood and lymphatic vessels
California - epidemiology
Cardiology. Vascular system
Child
Coronary aneurysm
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Fever
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetic Predisposition to Disease
Genome-Wide Association Study
Hawaii - epidemiology
Humans
Immunoglobulin A - biosynthesis
Immunoglobulins, Intravenous - therapeutic use
Incidence
Intravenous immunoglobulins
Medical sciences
Mucocutaneous lymph node syndrome
Mucocutaneous Lymph Node Syndrome - classification
Mucocutaneous Lymph Node Syndrome - diagnosis
Mucocutaneous Lymph Node Syndrome - epidemiology
Mucocutaneous Lymph Node Syndrome - genetics
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Abstract Kawasaki disease is an acute systemic vasculitis of unknown etiology. Diagnosis is based on clinical criteria that include fever, exanthema, conjunctivitis, changes in the extremities, erythema of oral mucosa and lips and cervical lymphadenopathy. However, these criteria have low sensitivity and specificity and therefore, other clinical and laboratory features may be helpful in establishing the diagnosis, especially for cases of atypical or incomplete Kawasaki disease. Prognosis depends on the extent of cardiac involvement; coronary aneurysms develop in 20–25% of untreated patients and these may lead to myocardial infarction and sudden death. Treatment with high-dose intravenous immunoglobulin is effective in reducing the risk of coronary aneurysms in most cases and is the treatment of choice for initial Kawasaki disease.
ISSN:0896-8411
1095-9157
DOI:10.1016/j.jaut.2014.01.010