Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon- beta sub(2)

Recombinant human interferon- beta sub(2) was produced in Escherichia coli) by direct expression of cDNA encoding the mature protein sequence. At concentrations that stimulate DNA synthesis and growth in B-cell hybridomas and plasmacytomas, the cytokine was found to exert a strong inhibition on the...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1988-01, Vol.85 (21), p.80-37-8041
Main Authors: Chen, L, Mory, Y, Zilberstein, A, Revel, M
Format: Article
Language:English
Online Access:Get full text
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Summary:Recombinant human interferon- beta sub(2) was produced in Escherichia coli) by direct expression of cDNA encoding the mature protein sequence. At concentrations that stimulate DNA synthesis and growth in B-cell hybridomas and plasmacytomas, the cytokine was found to exert a strong inhibition on the growth of a number of carcinoma and leukemia/lymphoma cell lines.
ISSN:0027-8424