Brønsted acid catalyzed cascade reactions of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes: a new approach to the synthesis of 2,2'-disubstituted 1H,1'H-3,3'-biindoles

An unusual Brønsted acid catalyzed cascade reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aryl(heteroaryl)aldehydes to afford an efficient alternative entry into 2,2'-disubstituted-1H,1'H-3,3'-biindoles under metal-free conditions is reported.

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Bibliographic Details
Published in:Organic letters 2014-03, Vol.16 (6), p.1736-1739
Main Authors: Arcadi, Antonio, Chiarini, Marco, D'Anniballe, Gaetano, Marinelli, Fabio, Pietropaolo, Emanuela
Format: Article
Language:English
Online Access:Get full text
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Summary:An unusual Brønsted acid catalyzed cascade reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aryl(heteroaryl)aldehydes to afford an efficient alternative entry into 2,2'-disubstituted-1H,1'H-3,3'-biindoles under metal-free conditions is reported.
ISSN:1523-7052
DOI:10.1021/ol500401p